热休克蛋白在乳腺癌中起作用吗？
Do heat shock proteins have a role in breast cancer?
作者信息
Conroy S E, Latchman D S
机构信息
Medical Molecular Biology Unit, Department of Molecular Pathology, London, UK.
出版信息
Br J Cancer. 1996 Sep;74(5):717-21. doi: 10.1038/bjc.1996.427.
Abstract
It is clear therefore that hsps are overexpressed in patients with malignant tumours compared with healthy controls and this overexpression does show some correlation with disease features. Furthermore, expression of hsps has been reported on the cell surface of tumour cell lines. This could be associated with the immune response which has been reported with hsp90 and which also correlates with some disease features. It now appears that hsps may be involved in the presentation of tumour antigens leading to the possibility of hsps being used as a means of therapy. Hsp65 expression has not been investigated in patients with breast cancer. However, transfection of bacterial hsp65 into a tumour cell line resulted in the hsp65-expressing tumour cells losing their tumorigenicity in mice (Lukacs et al., 1993). Thus, hsps and the immune response to them are of interest as diagnostic and prognostic tools as well as a novel form of immunotherapy.
摘要
因此，很明显，与健康对照相比，热休克蛋白在恶性肿瘤患者中过度表达，而且这种过度表达确实与疾病特征存在一定相关性。此外，已有报道称肿瘤细胞系的细胞表面存在热休克蛋白的表达。这可能与已报道的热休克蛋白90相关的免疫反应有关，并且也与一些疾病特征相关。现在看来，热休克蛋白可能参与肿瘤抗原的呈递，从而使热休克蛋白有可能被用作一种治疗手段。尚未对乳腺癌患者的热休克蛋白65表达进行研究。然而，将细菌热休克蛋白65转染到肿瘤细胞系中，导致表达热休克蛋白65的肿瘤细胞在小鼠体内失去致瘤性（卢卡奇等人，1993年）。因此，热休克蛋白及其免疫反应作为诊断和预后工具以及一种新型免疫疗法具有重要意义。
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