Choi T B, Noriega J F, Glasgow B J, Lee D A
Department of Ophthalmology, Jules Stein Eye Institute, UCLA School of Medicine 90024, USA.
J Glaucoma. 1996 Jun;5(3):176-81.
Contact versus noncontact transscleral neodymium:YAG laser cyclophotocoagulation was compared in a rabbit model with respect to the effects on intraocular pressure and pathologic findings.
Thirty-two rabbits received comparable energy levels (2 joules) of contact and noncontact cyclophotocoagulation. Pneumotonometry was performed every other day following treatment.
For both the 2-week and 8-week periods following treatment, intraocular pressure was significantly lower in eyes receiving contact cyclophotocoagulation than in eyes receiving noncontact cyclophotocoagulation (for the 2-week period, mean difference in intraocular pressure was 5.3 mm Hg, n = 22, p < 0.001; for the 8-week period, mean difference in intraocular pressure was 4.3 mm Hg, n = 17, p < 0.013). Pathologic findings include acute ciliary body hemorrhage and inflammation (1 day), chronic inflammation (1 week), granulation tissue within laser lesions (2 weeks), and marked ciliary body atrophy (8 weeks).
In our rabbit model, contact cyclophotocoagulation was more effective in lowering intraocular pressure than noncontact cyclophotocoagulation. Both contact and noncontact cyclophotocoagulation produced a variety of pathologic lesions in the rabbit eye, including cataract, phthisis bulbi, and anterior synechiae.
在兔模型中比较接触式与非接触式经巩膜钕：钇铝石榴石激光睫状体光凝术对眼压的影响及病理表现。
32只兔接受了能量水平相当（2焦耳）的接触式和非接触式睫状体光凝术。治疗后每隔一天进行眼压测量。
在治疗后的2周和8周期间，接受接触式睫状体光凝术的眼睛眼压显著低于接受非接触式睫状体光凝术的眼睛（2周时，眼压平均差异为5.3毫米汞柱，n = 22，p < 0.001；8周时，眼压平均差异为4.3毫米汞柱，n = 17，p < 0.013）。病理表现包括急性睫状体出血和炎症（1天）、慢性炎症（1周）、激光损伤内的肉芽组织（2周）以及明显的睫状体萎缩（8周）。
在我们的兔模型中，接触式睫状体光凝术在降低眼压方面比非接触式睫状体光凝术更有效。接触式和非接触式睫状体光凝术均在兔眼中产生了多种病理损害，包括白内障、眼球痨和前粘连。
