Kiene H
Kritik der klinischen Doppelblindstudie, Munich, Germany.
Altern Ther Health Med. 1996 Mar;2(2):59-64.
The randomized, double-blind study is generally regarded as the gold standard of clinical drug trials. Bias can occur as a result of the blinding procedure itself, but discussions of this type of bias have been few and far between. This article continues with a detailed discussion of such blinding errors, which can obscure genuine drug effects and be of a sufficient magnitude as to generate false-negative results. Uncritical blinding in clinical studies should therefore be questioned.
随机双盲研究通常被视为临床药物试验的金标准。由于盲法程序本身可能会出现偏差，但关于这类偏差的讨论却很少。本文将继续详细讨论此类盲法错误，这些错误可能会掩盖药物的真实效果，其严重程度足以产生假阴性结果。因此，临床研究中不加批判地采用盲法应受到质疑。
