腹水纤维连接蛋白和胆固醇浓度在鉴别恶性肿瘤相关性腹水与非恶性腹水方面的价值。

Value of ascitic fibronectin and cholesterol concentration in the differentiation between malignancy-related and non-malignant ascites.

作者信息

Archimandritis A, Kapsalas D, Douvara M, Tjivras M, Tsirantonaki M, Fertakis A

机构信息

Departement of Pathophysiology, University of Athens, Medical School, Laikon General Hospital, Greece.

出版信息

Ann Med Interne (Paris). 1996;147(3):145-50.

PMID:8796090

Abstract

In this prospective study, we tried to evaluate various "humoral tests of malignancy" regarding their efficiency of discriminating between malignancy-related and non-malignant ascites. Fibronectin, total protein, number of cells, LDH, pH, specific gravity and cytology were compared in the ascitic fluid of 51 patients with malignancy-related and 52 patients with non-malignant ascites; patients with tuberculous peritonitis were not included. Ascitic fluid cholesterol was determined in 36 of 51 malignancy-related and in 37 of 52 non-malignant ascites. Cytology and fibronectin were found 100% specific with diagnostic efficiency 87.5% and 94.2% respectively under optimal conditions. Cholesterol was neither sensitive nor specific. It is concluded that fibronectin was a valuable test for malignancy-associated ascites.

摘要

在这项前瞻性研究中，我们试图评估各种“恶性肿瘤体液检测”在区分恶性肿瘤相关性腹水和非恶性腹水方面的有效性。对51例恶性肿瘤相关性腹水患者和52例非恶性腹水患者的腹水进行了纤连蛋白、总蛋白、细胞数量、乳酸脱氢酶（LDH）、pH值、比重及细胞学检查；未纳入结核性腹膜炎患者。在51例恶性肿瘤相关性腹水中的36例以及52例非恶性腹水中的37例测定了腹水胆固醇。在最佳条件下，细胞学和纤连蛋白的特异性均为100%，诊断效率分别为87.5%和94.2%。胆固醇既不敏感也无特异性。结论是纤连蛋白是检测恶性肿瘤相关性腹水的一项有价值的检测方法。