Adamsen S, Jönsson P, Brodin B, Lindberg B, Jorpes P
Department of General Surgery, Halmstad County Hospital, Sweden.
Eur J Surg. 1991 May;157(5):325-8.
Fifty-eight consecutive patients who were admitted to two departments of general surgery with ascites of unknown origin were investigated by measurement of ascitic fluid fibronectin concentration in a prospective study. A fibronectin concentration of 100 ml/l or more was chosen as indicative of malignant disease. In 40 patients with malignant disease, the median fibronectin concentration was 160 mg/l (interquartile range 120-270, range 20-560). In 18 patients with ascites from benign disease the corresponding figures were 40 mg/l (30-70, 20-90) (p less than 0.01). The diagnostic specificity (predictive value of a positive test) was 1.00 (34/34) (95% confidence interval 0.90 to 1.00), while the diagnostic sensitivity (predictive value of a negative test) was 0.75 (18/24) (95% CI 0.53 to 0.90). In this series an ascitic fluid fibronectin concentration of 100 mg/l or more indicated malignant disease, but a lower value did not exclude it. The test should be investigated in combination with another test with high diagnostic sensitivity to optimise its diagnostic value.
在一项前瞻性研究中，对连续收治到两个普通外科科室的58例不明原因腹水患者进行了腹水纤维连接蛋白浓度测定。以100mg/l或更高的纤维连接蛋白浓度作为恶性疾病的指标。40例恶性疾病患者中，纤维连接蛋白浓度中位数为160mg/l（四分位间距120 - 270，范围20 - 560）。18例良性疾病腹水患者的相应数值为40mg/l（30 - 70，20 - 90）（p<0.01）。诊断特异性（阳性试验预测值）为1.00（34/34）（95%置信区间0.90至1.00），而诊断敏感性（阴性试验预测值）为0.75（18/24）（95%CI 0.53至0.90）。在本系列研究中，腹水纤维连接蛋白浓度100mg/l或更高提示恶性疾病，但较低值并不能排除恶性疾病。该试验应与另一项诊断敏感性高的试验联合进行研究，以优化其诊断价值。
