正常青少年和胰岛素依赖型糖尿病青少年的血清胰岛素样生长因子II水平。

Serum insulin-like growth factor II levels in normal adolescents and those with insulin dependent diabetes mellitus.

作者信息

Acerini C L, Clayton K L, Hintz R, Baker B, Watts A, Holly J M, Dunger D B

机构信息

Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, UK.

出版信息

Clin Endocrinol (Oxf). 1996 Jul;45(1):13-9.

PMID:8796133

Abstract

OBJECTIVE

Unlike IGF-I and its principal binding proteins, data regarding IGF-II levels have not been well defined in normal subjects and those with insulin-dependent diabetes mellitus (IDDM). We have therefore measured IGF-II, as well as IGF-I, and IGFBP-3, levels in a large cohort of subjects with IDDM and in age/sex matched controls.

PATIENTS

One hundred and fourteen patients with IDDM (57 males, 57 females) and 89 control subjects (49 males, 40 females).

MEASUREMENTS

Random blood samples were obtained from each subject for the measurement of IGF-II, IGF-I and IGFBP-3 levels.

RESULTS

Mean values of IGF-II (+/- SEM) were 630 (+/- 27.8) micrograms/l and 646 (+/- 32.3) micrograms/l in female and male controls, compared to 569 (+/- 23.3) micrograms/l and 623.3 (+/- 28.1) micrograms/l in female and male diabetics respectively. IGF-II levels did not differ significantly between the sexes or show any change with transition through puberty in either control or diabetic groups. In contrast, IGF-I levels increased through puberty peaking at stages 3-5 in controls (P < 0.001) and G4-5 (P = 0.002) in diabetic males but not females. IGF-I levels in all diabetics were generally lower than in controls, differences reaching significance at G4-5 in males (P = 0.002) and B5 in females (P = 0.002). IGFBP-3 levels did not show any variation with puberty stage in diabetics, in contrast to controls where levels increased, peaking at G4-5 in males (P = 0.001) and B3 in females. IGFBP-3 levels were lower in diabetics of both sexes and at all stages compared to controls (P range 0.047 to < 0.001). Multiple regression analysis revealed significant correlations between IGF-II and IGFBP-3 (F = 20.1, P = < 0.001) and reaffirmed previously observed associations for IGF-I and IGFBP-3. The sum of IGF-I and IGF-II (expressed as nmol/l) correlated with IGFBP-3; r = 0.47 in controls and 0.60 in diabetics.

CONCLUSIONS

Insulin-dependent diabetes mellitus is not associated with any significant changes in IGF-II levels during puberty. The binding of IGFBP-3 for both IGF-I and IGF-II is unaltered by insulin-dependent diabetes mellitus.

摘要

目的

与胰岛素样生长因子-I（IGF-I）及其主要结合蛋白不同，关于正常受试者和胰岛素依赖型糖尿病（IDDM）患者的胰岛素样生长因子-II（IGF-II）水平的数据尚未明确界定。因此，我们测量了一大群IDDM患者以及年龄/性别匹配的对照组中IGF-II、IGF-I和胰岛素样生长因子结合蛋白-3（IGFBP-3）的水平。

患者

114例IDDM患者（57例男性，57例女性）和89例对照受试者（49例男性，40例女性）。

测量

从每个受试者采集随机血样以测量IGF-II、IGF-I和IGFBP-3水平。

结果

女性和男性对照组中IGF-II（±标准误）的平均值分别为630（±27.8）μg/L和646（±32.3）μg/L，而女性和男性糖尿病患者中分别为569（±23.3）μg/L和623.3（±28.1）μg/L。在对照组或糖尿病组中，IGF-II水平在性别之间没有显著差异，并且在青春期过渡期间也没有任何变化。相比之下，对照组中IGF-I水平在青春期升高，在3-5期达到峰值（P<0.001），糖尿病男性在G4-5期达到峰值（P = 0.002），而女性没有。所有糖尿病患者的IGF-I水平总体上低于对照组，男性在G4-5期（P = 0.002）和女性在B5期（P = 0.002）差异显著。与对照组不同，糖尿病患者的IGFBP-3水平在青春期阶段没有任何变化，对照组中IGFBP-3水平升高，男性在G4-5期达到峰值（P = 0.001），女性在B3期达到峰值。与对照组相比，糖尿病患者两性在所有阶段的IGFBP-3水平均较低（P范围为0.047至<0.001）。多元回归分析显示IGF-II与IGFBP-3之间存在显著相关性（F = 20.1，P =<0.001），并再次证实了先前观察到的IGF-I与IGFBP-3之间的关联。IGF-I和IGF-II的总和（以nmol/L表示）与IGFBP-3相关；对照组中r = 0.47，糖尿病患者中r = 0.60。