HLA-DR和-DO表型对肺结核患者结核菌素反应状态的影响。
Influence of HLA-DR and -DO phenotypes on tuberculin reactive status in pulmonary tuberculosis patients.
作者信息
Selvaraj P, Reetha A M, Uma H, Xavier T, Janardhanam B, Prabhakar R, Narayanan P R
机构信息
Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India.
出版信息
Tuber Lung Dis. 1996 Aug;77(4):369-73. doi: 10.1016/s0962-8479(96)90104-5.
SETTING
HLA and tuberculin status in pulmonary tuberculosis patients. Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India.
OBJECTIVE
To elucidate the role of HLA-class-II genes/gene products on tuberculin reactivity in pulmonary tuberculosis patients.
DESIGN
Serological determination of HLA-DR and -DQ antigens was carried out in 62 healthy control subjects and 146 pulmonary tuberculosis patients. The tuberculin reaction pattern of pulmonary tuberculosis patients to PPD was studied and the role of HLA-DR and -DQ antigens (class-II gene products) on tuberculin reaction was analysed.
RESULTS
HLA-DR and -DQ antigens did not influence high, medium and low tuberculin reaction dramatically in active pulmonary tuberculosis patients. However, a heterozygous combination of various HLA-DR antigens influenced the tuberculin reaction.
CONCLUSION
The HLA-genetic make up (heterozygous combination) of the individual may influence the tuberculin reaction pattern in pulmonary tuberculosis.
背景
肺结核患者的HLA及结核菌素状态。印度马德拉斯市印度医学研究理事会结核病研究中心。
目的
阐明HLA-II类基因/基因产物在肺结核患者结核菌素反应性中的作用。
设计
对62名健康对照者和146名肺结核患者进行了HLA-DR和-DQ抗原的血清学检测。研究了肺结核患者对PPD的结核菌素反应模式，并分析了HLA-DR和-DQ抗原（II类基因产物）对结核菌素反应的作用。
结果
在活动性肺结核患者中，HLA-DR和-DQ抗原对高、中、低结核菌素反应没有显著影响。然而，各种HLA-DR抗原的杂合组合会影响结核菌素反应。
结论
个体的HLA基因组成（杂合组合）可能会影响肺结核患者的结核菌素反应模式。
Zotero 插件