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在健康羔羊中，吸入前列环素（PGI2）8小时不会产生急性肺毒性迹象。

Inhalation of prostacyclin (PGI2) for 8 hours does not produce signs of acute pulmonary toxicity in healthy lambs.

作者信息

Habler O, Kleen M, Zwissler B, Pusch R, Welte M, Vogelmeier C, Kempter B, Krombach F, Messmer K

机构信息

Institute for Surgical Research, Ludwig-Maximilians-University, Munich, Germany.

出版信息

Intensive Care Med. 1996 May;22(5):426-33. doi: 10.1007/BF01712159.

DOI:10.1007/BF01712159
PMID:8796394
Abstract

OBJECTIVE

To study the potential side effects and toxicity of inhaling prostacyclin (PGI2) aerosol for 8 h.

DESIGN

In a prospective, randomized study 14 healthy lambs received either PGI2 (n = 7) or 0.9% NaCl (n = 7) as an aerosol for 8 h.

SETTING

Institute for Surgical Research of the Ludwig-Maximilians-University of Munich.

INTERVENTIONS

All animals were studied under general anesthesia in a prone position. They were first intubated endotracheally and later tracheotomized. PGI2 solution (median dose 28 ng/kg per min) or 0.9% NaCl was administered with a jet nebulizer (delivery rate 4-10 ml/h; mass median diameter of aerosol particles 3.1 microns). Bronchoalveolar lavage was performed before and after the inhalation period to collect epithelial lining fluid of alveoli.

MEASUREMENTS AND RESULTS

Hemodynamic and respiratory parameters, systemic resorption (plasma levels of 6-keto-prostaglandin-F 1 alpha), in vitro bleeding time, collagen-induced platelet aggregation and global biochemical and cellular composition of the epithelial lining fluid were examined in order to assess the side effects and signs of acute pulmonary toxicity induced by inhaled PGI2. No statistically significant differences were found between the PGI2 and the control groups for any of the parameters examined.

CONCLUSION

Inhalation of PGI2 (28 ng/kg per min) over a period of 8 h in healthy lambs does not produce major side effects or acute pulmonary toxicity.

摘要

目的

研究吸入前列环素（PGI2）气雾剂8小时的潜在副作用和毒性。

设计

在一项前瞻性随机研究中，14只健康羔羊接受PGI2（n = 7）或0.9%氯化钠（n = 7）气雾剂吸入8小时。

地点

慕尼黑路德维希 - 马克西米利安大学外科研究所。

干预措施

所有动物在全身麻醉下俯卧位进行研究。首先经气管内插管，随后行气管切开术。PGI2溶液（中位剂量28 ng/kg每分钟）或0.9%氯化钠通过喷射雾化器给药（输送速率4 - 10 ml/小时；气溶胶颗粒质量中位直径3.1微米）。在吸入期前后进行支气管肺泡灌洗以收集肺泡上皮衬液。

测量与结果

检测血流动力学和呼吸参数、全身吸收情况（血浆6 - 酮 - 前列腺素 - F1α水平）、体外出血时间、胶原诱导的血小板聚集以及上皮衬液的整体生化和细胞组成，以评估吸入PGI2引起的副作用和急性肺毒性迹象。在PGI2组和对照组之间，所检测的任何参数均未发现统计学上的显著差异。

结论

健康羔羊吸入PGI2（28 ng/kg每分钟）8小时不会产生主要副作用或急性肺毒性。

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