Bogner P, Berényi E, Miseta A, Horn P, Kellermayer M, Wheatley D N, Jolesz F A
Diagnostic Center, Pannon University of Agriculture, Kaposvár, Hungary.
Acad Radiol. 1996 Jan;3(1):26-30. doi: 10.1016/s1076-6332(96)80328-x.
The malignant hyperthermia (MH) syndrome involves characteristic changes in metabolism that have a significant effect on the postmortem properties of muscle tissue. We investigated the 1H nuclear magnetic resonance (MR) relaxation parameters of muscle tissue from normal (MH-) and malignant hyperthermia-susceptible (MH+) swine taken before their death to identify whether postmortem metabolic differences would be accompanied by changes in relaxation parameters.
Muscle samples from 63 MH-susceptible swine were characterized by proton MR relaxation times (T1 and T2). The water content, pH, conducting, and the "subjective meat" quality were assessed in order to differentiate the meat into one of three groups: normal, pale-soft-exudative, and dark-firm-dry.
The T2 relaxation of MH- and MH+ muscles was significantly different, but no significant changes were detected in the water content and corresponding T1 relaxation times.
These data suggest that MH-susceptible swine can be distinguished from normal swine using nuclear MR relaxometry. The results of relaxation measurements and the multiexponential analysis of the T2 curves suggest a shift between the different water compartments during MH that might predict the increased water loss of muscle tissue after death.
恶性高热（MH）综合征涉及代谢的特征性变化，对肌肉组织的死后特性有显著影响。我们研究了正常（MH-）和恶性高热易感（MH+）猪在死亡前肌肉组织的1H核磁共振（MR）弛豫参数，以确定死后代谢差异是否会伴随弛豫参数的变化。
对63头恶性高热易感猪的肌肉样本进行质子MR弛豫时间（T1和T2）测定。评估肌肉的含水量、pH值、导电性和“主观肉质”质量，以便将肉分为三组之一：正常、苍白-柔软-渗出性和深色-坚硬-干燥。
MH-和MH+肌肉的T2弛豫有显著差异，但含水量和相应的T1弛豫时间未检测到显著变化。
这些数据表明，使用核磁共振弛豫测量法可以区分恶性高热易感猪和正常猪。弛豫测量结果和T2曲线的多指数分析表明，在恶性高热期间不同水相之间发生了转移，这可能预示着死后肌肉组织水分流失增加。
