Rogers S W, Twyman R E, Gahring L C
VA Medical Center, Salt Lake City, UT, USA.
Mol Med Today. 1996 Feb;2(2):76-81. doi: 10.1016/1357-4310(96)88742-9.
Understanding and experimentally approaching the processes that underlie the origin and progression of many severe neurological disorders presents a challenge to both clinical and basic researchers. We have found that the origin of some neurological diseases, including a rare form of childhood epilepsy and a neurodegenerative disease associated with peripheral cancers, may be related to production of physiologically active autoantibodies that are directed towards excitatory ionotropic glutamate receptors of the brain. This suggests that some neurological diseases may result from dysfunction of the immune system.
理解并通过实验探究许多严重神经系统疾病的起源和进展背后的过程，对临床和基础研究人员来说都是一项挑战。我们发现，一些神经系统疾病的起源，包括一种罕见的儿童癫痫形式以及一种与外周癌症相关的神经退行性疾病，可能与针对大脑兴奋性离子型谷氨酸受体的生理活性自身抗体的产生有关。这表明一些神经系统疾病可能是免疫系统功能障碍所致。
