使用万维网的序列数据库和同源性搜索。
Sequence databases and homology searching using the World Wide Web.
作者信息
Paterson M
机构信息
Department of Medicine, St. Mary's Hospital Medical School, Imperial College, London, UK
出版信息
Mol Med Today. 1996 Mar;2(3):98-102. doi: 10.1016/1357-4310(96)88718-1.
RNA, DNA and protein sequence data produced in laboratories around the world may be freely accessed by other scientists using the Internet. Originally, these sequence databases were compiled from published literature, but now researchers may deposit sequence data directly, using the World Wide Web. Almost 50,000 protein sequences and over 600,000 nucleotide sequences are available, forming a significant scientific resource. By comparing novel sequence data with sequence entries and structural data showing significant homology, it is possible to predict the function and three-dimensional structure of novel proteins.
世界各地实验室产生的RNA、DNA和蛋白质序列数据可供其他科学家通过互联网免费获取。最初，这些序列数据库是根据已发表的文献汇编而成的，但现在研究人员可以使用万维网直接存入序列数据。目前已有近50000个蛋白质序列和超过600000个核苷酸序列，形成了一项重要的科学资源。通过将新的序列数据与显示出显著同源性的序列条目和结构数据进行比较，就有可能预测新蛋白质的功能和三维结构。
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