Winqvist O, Söderbergh A, Kämpe O
Department of Internal Medicine, University Hospital, Uppsala University, Sweden.
Mol Med Today. 1996 Jul;2(7):282-9. doi: 10.1016/1357-4310(96)10024-1.
Addison's disease is mainly caused by autoimmune destruction of the steroid-producing cells in the adrenal glands. Key enzymes in steroid biosynthesis have been implicated as the major targets of autoantibodies in this disease. The study of B-cell-dependent autoimmune responses reveals two distinguishable forms of Addison's disease. This should permit very accurate diagnosis of the disease and increase future prospects of disease prevention.
艾迪生病主要由肾上腺中产生类固醇的细胞的自身免疫性破坏引起。类固醇生物合成中的关键酶被认为是该疾病自身抗体的主要靶标。对B细胞依赖性自身免疫反应的研究揭示了艾迪生病的两种不同形式。这将有助于非常准确地诊断该疾病，并增加疾病预防的未来前景。
