Cilleruelo Pascual M L, Urruzuno Tellería P, Román Riechman E, Medina Benítez E, Manzanares López-Manzanares J, Echávarri Olavarría F, Molina Arias M
Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid.
An Esp Pediatr. 1996 May;44(5):456-60.
The aim of this study was to assess the clinical outcome of two different durations of triple therapy in children with Helicobacter pylori infection. We established two treatment groups: 1) Short treatment, including 2 week of bismuth subcitrate, amoxycillin and metronidazole treatment (n = 21) and 2) Long treatment, which included the same therapy for two weeks plus bismuth subcitrate alone for two weeks more (n = 26). We found no difference between the short and long treatments. The infection remained in 14% and 19%, respectively. In both groups, we observed children (19%) with persistent abdominal pain in spite of Helicobacter pylori eradication and gastritis healing. We conclude that it is not necessary to prolong triple therapy more than 2 weeks in order to have therapeutic success.
本研究的目的是评估两种不同疗程的三联疗法对幽门螺杆菌感染儿童的临床疗效。我们设立了两个治疗组：1）短疗程治疗组，包括2周的枸橼酸铋钾、阿莫西林和甲硝唑治疗（n = 21）；2）长疗程治疗组，包括相同疗法治疗2周，再加用2周的枸橼酸铋钾单药治疗（n = 26）。我们发现短疗程和长疗程治疗之间没有差异。感染持续存在的比例分别为14%和19%。在两组中，我们都观察到尽管幽门螺杆菌已根除且胃炎已愈合，但仍有19%的儿童存在持续性腹痛。我们得出结论，为了取得治疗成功，没有必要将三联疗法延长超过2周。
