Kawai S, Okada R, Sakurai H, Yamaguchi H, Fukuda Y
Department of Cardiology, Juntendo University, School of Medicine, Tokyo.
Intern Med. 1996 May;35(5):383-7. doi: 10.2169/internalmedicine.35.383.
Marked arteriosclerosis localized to the descending thoracic and abdominal aorta was observed in a 19-year-old girl with interruption of the aorta (type A) and a ventricular septal defect. She died from rupture of saccular aneurysm of the pulmonary trunk. The descending thoracic and abdominal aorta showed marked thrombogenic, lamellar thickening of the intima. In contrast, no significant arteriosclerosis was detected in the ascending aorta. Several factors including diffuse sludging of blood, mural thrombosis and hemodynamic changes, in close association with polycythemia, are hypothesized to be causative factors in the development of this lesion.
在一名患有主动脉中断（A型）和室间隔缺损的19岁女孩中，观察到明显的动脉硬化局限于胸降主动脉和腹主动脉。她死于肺动脉干囊状动脉瘤破裂。胸降主动脉和腹主动脉显示内膜有明显的血栓形成性、板层增厚。相比之下，升主动脉未检测到明显的动脉硬化。包括血液弥漫性淤滞、壁血栓形成和血流动力学变化在内的几个因素，与红细胞增多症密切相关，被认为是该病变发生的致病因素。
