Yamauchi A, Amano K, Ichikawa Y, Nakamoto S, Takei I, Maruyama H, Kono N, Saruta T
Department of Internal Medicine, School of Medicine, Keio University, Tokyo.
Intern Med. 1996 May;35(5):403-6. doi: 10.2169/internalmedicine.35.403.
A 64-year-old female with McArdle's disease and non-insulin-dependent diabetes mellitus (NIDDM) is reported. She had none of the characteristic symptoms of McArdle's disease such as muscle cramps but her serum creatine kinase level was elevated. Muscle biopsy with negative muscle phosphorylase staining showed McArdle's disease. Modified forearm ischemic exercise test was done at two conditions; fasting and two hours after a meal. When fasting, the level of lactic acid did not elevate after exercise. After a meal, however, the serum lactic acid level rose with the elevation of plasma glucose and IRI. Thus, we suggested that high plasma glucose and insulin due to NIDDM may induce blood-borne glucose uptake with exercise.
报告了一名64岁患有麦克尔病和非胰岛素依赖型糖尿病（NIDDM）的女性。她没有麦克尔病的典型症状，如肌肉痉挛，但血清肌酸激酶水平升高。肌肉活检显示肌肉磷酸化酶染色阴性，确诊为麦克尔病。在两种情况下进行了改良的前臂缺血运动试验：空腹和进食后两小时。空腹时，运动后乳酸水平未升高。然而，进食后，血清乳酸水平随血糖和胰岛素释放指数（IRI）的升高而上升。因此，我们认为NIDDM导致的高血糖和高胰岛素水平可能会促使运动时血液中的葡萄糖被摄取利用。
