Mück A O, Seeger H, Bartsch C, Lippert T H
Department of OB/GYN, University Women's Hospital, Tuebingen, Germany.
J Pineal Res. 1996 Apr;20(3):145-7. doi: 10.1111/j.1600-079x.1996.tb00250.x.
The pineal hormone melatonin showed no effect on voltage-gated calcium channels in cultured human aortic smooth muscle cells. In combination with estradiol, which blocked calcium channels, melatonin did not antagonize the effect of estradiol. It is concluded that melatonin seems to have different effects on voltage-gated calcium channels of divergent cell types since the positive action of melatonin previously observed on rat cardiac membranes by other authors could not be seen in the present investigations with human vascular smooth muscle cells.
松果体激素褪黑素对培养的人主动脉平滑肌细胞中的电压门控钙通道没有影响。与阻断钙通道的雌二醇联合使用时，褪黑素并未拮抗雌二醇的作用。得出的结论是，褪黑素似乎对不同细胞类型的电压门控钙通道有不同的作用，因为其他作者先前在大鼠心肌膜上观察到的褪黑素的积极作用在目前对人血管平滑肌细胞的研究中并未出现。
