Kutsutani-Nakamura Y, Furukawa S, Tabushi K, Akanuma A, Kubota S, Nakano T, Morita S, Fukuhisa K, Arai T
Department of Radiotherapy, Saitama Cancer Center.
Nihon Igaku Hoshasen Gakkai Zasshi. 1996 Jul;56(8):570-4.
Intracavitary irradiation therapy for carcinoma of the uterine cervix used with high or low dose rate irradiation is fractionated in Japan. The optimal treatment dose is determined according to the biological effect on both diseased and healthy tissues. The equations of modified NSD and TDF biological equivalents were recalculated from Arai's clinical data, which were used to examine the optimal time-dose-fractionation relationship for high and low dose rate intracavitary irradiation on squamous cell carcinoma of the cervix uteri. The optimal time-dose-fractionation relationship at point A is expressed as follows: D = NSD N0.26 T0.06 where NSD is 17.75 get for high dose rate and 31.78 get for low dose rate. TDF = K n d1.47 x-0.09 where K is 1.46 for high dose rate and 0.62 for low dose rate. The range of the optimal total dose to point A given by one fraction per week was 30.7 Gy for 4 fractions and 38.3 Gy for 8 fractions in high dose rate irradiation. In the case of low dose rate irradiation, the optimal total dose given by one fraction per week and the dose rate of 75.0 cGy/h was 55.0 Gy for 4 fractions. The maximum dose difference between our result and Arai's was about +/- 10%. The dose modification ratio for high dose rate and low dose rate is 1.79.
在日本，子宫颈癌腔内照射治疗采用高剂量率或低剂量率照射，并进行分次照射。根据对病变组织和健康组织的生物学效应来确定最佳治疗剂量。根据新井的临床数据重新计算了改良的NSD和TDF生物等效性方程，这些数据用于研究子宫颈鳞状细胞癌高剂量率和低剂量率腔内照射的最佳时间-剂量-分次关系。A点的最佳时间-剂量-分次关系如下表示：D = NSD N0.26 T0.06，其中高剂量率时NSD为17.75 get，低剂量率时为31.78 get。TDF = K n d1.47 x-0.09，其中高剂量率时K为1.46，低剂量率时为0.62。高剂量率照射时，每周一次分次照射至A点的最佳总剂量范围为4次分次照射时30.7 Gy，8次分次照射时38.3 Gy。在低剂量率照射的情况下，每周一次分次照射且剂量率为75.0 cGy/h时，4次分次照射的最佳总剂量为55.0 Gy。我们的结果与新井的结果之间的最大剂量差异约为±10%。高剂量率和低剂量率的剂量修正率为1.79。
