• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

单次肌内注射后阿米卡星在儿童血清、肌肉和脂肪中的分布情况。

Distribution of amikacin in serum, muscle, and fat in children after a single intramuscular injection.

作者信息

Daschner F, Reiss E, Engert J

出版信息

Antimicrob Agents Chemother. 1977 Jun;11(6):1081-3. doi: 10.1128/AAC.11.6.1081.

DOI:10.1128/AAC.11.6.1081
PMID:879756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352136/
Abstract

Amikacin concentrations in serum, muscle, and fat were determined in 41 children after intramuscular administration of 7.5 mg/kg of body weight. At 1.5 h amikacin reached peak concentrations in serum (mean value, 14.9 mug/ml) as well as in muscle (2.2 mug/g) and fat (1.89 mug/g) tissue; from then on all concentrations declined. Amikacin concentrations exceeded 1 mug/g in muscle for at least 3 h and in fat for at least 4 h.

摘要

对41名儿童肌肉注射7.5毫克/千克体重的丁胺卡那霉素后，测定了血清、肌肉和脂肪中的丁胺卡那霉素浓度。1.5小时时，丁胺卡那霉素在血清（平均值为14.9微克/毫升）、肌肉（2.2微克/克）和脂肪（1.89微克/克）组织中均达到峰值浓度；此后所有浓度均下降。丁胺卡那霉素在肌肉中的浓度至少3小时超过1微克/克，在脂肪中至少4小时超过1微克/克。

相似文献

1
Distribution of amikacin in serum, muscle, and fat in children after a single intramuscular injection.单次肌内注射后阿米卡星在儿童血清、肌肉和脂肪中的分布情况。
Antimicrob Agents Chemother. 1977 Jun;11(6):1081-3. doi: 10.1128/AAC.11.6.1081.
2
Disposition studies with amikacin after rapid intravenous and intramuscular administration to human volunteers.
J Antimicrob Chemother. 1978 Jul;4(4):335-41. doi: 10.1093/jac/4.4.335.
3
Pharmacokinetics of amikacin in the horse following intravenous and intramuscular administration.
J Vet Pharmacol Ther. 1985 Jun;8(2):194-201. doi: 10.1111/j.1365-2885.1985.tb00944.x.
4
Pharmacokinetics of amikacin in pony foals after a single intramuscular injection.
Am J Vet Res. 1986 Feb;47(2):453-4.
5
Clinical pharmacology of amikacin and kanamycin.阿米卡星和卡那霉素的临床药理学
J Infect Dis. 1976 Nov;134 SUPPL:S312-5. doi: 10.1093/infdis/135.supplement_2.s312.
6
Pharmacokinetics of amikacin in infants and pre-school children.阿米卡星在婴幼儿及学龄前儿童中的药代动力学
Acta Paediatr Scand. 1979 May;68(3):419-22. doi: 10.1111/j.1651-2227.1979.tb05030.x.
7
Kinetics and dose calculations of amikacin in the newborn.新生儿中阿米卡星的动力学及剂量计算
Clin Pharmacol Ther. 1976 Jul;20(1):59-66. doi: 10.1002/cpt197620159.
8
Amikacin sulfate in mares: pharmacokinetics and body fluid and endometrial concentrations after repeated intramuscular administration.硫酸阿米卡星在母马体内的研究：重复肌肉注射后的药代动力学、体液及子宫内膜浓度
Am J Vet Res. 1984 Aug;45(8):1610-3.
9
[Absorption, excretion and distribution of amikacin following intravenous drip infusion. Intravenous drip infusion, one shot intravenous injection and intramuscular administration of amikacin in dogs, rabbits and rats].阿米卡星静脉滴注后的吸收、排泄及分布。犬、兔和大鼠静脉滴注、单次静脉注射及肌内注射阿米卡星的情况
Jpn J Antibiot. 1982 Aug;35(8):2034-46.
10
[Pharmacokinetics of amikacin in bronchial secretions].[阿米卡星在支气管分泌物中的药代动力学]
Nouv Presse Med. 1979 Oct 31;8(42):3441-4.

引用本文的文献

1
Modification in the pharmacokinetics of amikacin during development.阿米卡星在研发过程中的药代动力学变化。
Eur J Clin Pharmacol. 1982;23(2):155-60. doi: 10.1007/BF00545971.

本文引用的文献

1
Stomaching: a new concept in bacteriological sample preparation.胃孵育法：细菌学样本制备中的一个新概念。
Appl Microbiol. 1972 Aug;24(2):175-8. doi: 10.1128/am.24.2.175-178.1972.
2
Penetration of antibiotics into fibrin loci in vivo. 3. Intermittent vs. continuous infusion and the effect of probenecid.
J Infect Dis. 1974 Jan;129(1):73-8. doi: 10.1093/infdis/129.1.73.
3
Pharmacological evaluation of amikacin in neonates.阿米卡星在新生儿中的药理学评估。
Antimicrob Agents Chemother. 1975 Jul;8(1):86-90. doi: 10.1128/AAC.8.1.86.