单次肌内注射后阿米卡星在儿童血清、肌肉和脂肪中的分布情况。
Distribution of amikacin in serum, muscle, and fat in children after a single intramuscular injection.
作者信息
Daschner F, Reiss E, Engert J
出版信息
Antimicrob Agents Chemother. 1977 Jun;11(6):1081-3. doi: 10.1128/AAC.11.6.1081.
Abstract
Amikacin concentrations in serum, muscle, and fat were determined in 41 children after intramuscular administration of 7.5 mg/kg of body weight. At 1.5 h amikacin reached peak concentrations in serum (mean value, 14.9 mug/ml) as well as in muscle (2.2 mug/g) and fat (1.89 mug/g) tissue; from then on all concentrations declined. Amikacin concentrations exceeded 1 mug/g in muscle for at least 3 h and in fat for at least 4 h.
摘要
对41名儿童肌肉注射7.5毫克/千克体重的丁胺卡那霉素后，测定了血清、肌肉和脂肪中的丁胺卡那霉素浓度。1.5小时时，丁胺卡那霉素在血清（平均值为14.9微克/毫升）、肌肉（2.2微克/克）和脂肪（1.89微克/克）组织中均达到峰值浓度；此后所有浓度均下降。丁胺卡那霉素在肌肉中的浓度至少3小时超过1微克/克，在脂肪中至少4小时超过1微克/克。
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