Regimbald L H, Pilarski L M, Longenecker B M, Reddish M A, Zimmermann G, Hugh J C
Department of Laboratory Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada.
Cancer Res. 1996 Sep 15;56(18):4244-9.
The MUC 1 mucin is expressed on normal breast epithelium and in 90% of breast cancers. We report here that tumor-associated MUC1 is a ligand for intercellular adhesion molecule 1 (ICAM-1). Antibodies to ICAM-1 and to MUC1 inhibited adhesion of human and transfected mouse MUC1-positive cell lines to human umbilical vein endothelial cell monolayers and immobilized recombinant human ICAM-1-immunoglobulin fusion protein. Purified MUC1 pretreatment of recombinant human ICAM-1 was an equally effective inhibitor of adhesion. The interaction between MUC1 and ICAM-1 may be critical to the process of bloodborne metastases in breast cancer.
MUC1黏蛋白在正常乳腺上皮及90%的乳腺癌中表达。我们在此报告，肿瘤相关的MUC1是细胞间黏附分子1（ICAM-1）的配体。针对ICAM-1和MUC1的抗体抑制了人和转染的小鼠MUC1阳性细胞系与人脐静脉内皮细胞单层以及固定化重组人ICAM-1免疫球蛋白融合蛋白的黏附。重组人ICAM-1经纯化的MUC1预处理同样是有效的黏附抑制剂。MUC1与ICAM-1之间的相互作用可能对乳腺癌血行转移过程至关重要。
