Ko S, Nakajima Y, Kanehiro H, Kin T, Aomatsu Y, Yoshimura A, Taki J, Yagura K, Ohashi K, Nakano H
First Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634, Japan.
World J Surg. 1996 Oct;20(8):1082-6. doi: 10.1007/s002689900164.
The purpose of this study was to investigate the relation between the recurrence of hepatocellular carcinoma (HCC) and the histologic status of underlying chronic liver disease from a viewpoint of multicentric hepatocarcinogenesis. Sixty-eight patients who underwent curative resection of HCC and have been followed for more than 2 years are reported. Based on the microscopic findings of the noncancerous part of the liver, the patients were divided into normal liver (N,n = 2), chronic persistent hepatitis (CPH,n = 6), chronic aggressive hepatitis (CAH,n = 31), and liver cirrhosis (LC,n = 29) according to a classification by the European Association for the Study of the Liver. Background data for the groups showed no significant differences. Recurrence was observed in none of the patients in the N and CPH groups, 26 (83.9%) of the patients in the CAH group, and 12 (41.4%) of the patients in the LC group. The cumulative disease-free survival rate of the CAH group was significantly lower than that of the CPH group (p < 0.05) and LC group (p < 0.01). This study revealed that the histologic status of the underlying chronic liver disease influenced the recurrence rate in patients with HCC. CAH was considered to be a risk factor for recurrence after resection of HCC.
本研究旨在从多中心肝癌发生的角度，探讨肝细胞癌（HCC）复发与潜在慢性肝病组织学状态之间的关系。报告了68例行HCC根治性切除且随访超过2年的患者。根据肝脏非癌部分的显微镜检查结果，按照欧洲肝脏研究协会的分类，将患者分为正常肝脏组（N，n = 2）、慢性持续性肝炎组（CPH，n = 6）、慢性活动性肝炎组（CAH，n = 31）和肝硬化组（LC，n = 29）。各组的背景数据无显著差异。N组和CPH组患者均未观察到复发，CAH组26例（83.9%）患者复发，LC组12例（41.4%）患者复发。CAH组的累积无病生存率显著低于CPH组（p < 0.05）和LC组（p < 0.01）。本研究表明，潜在慢性肝病的组织学状态影响HCC患者的复发率。CAH被认为是HCC切除术后复发的危险因素。
