Koo W H, Knight L A, Ang P T
Department of Medical Oncology, Singapore General Hospital, Singapore.
Ann Acad Med Singap. 1996 Mar;25(2):289-92.
Fanconi's anaemia is a rare genetic disorder and majority of the patients die of haematologic complications in their second or third decades of life. Others who have mild or no cytopenias survive long enough to develop malignancies. This is a report of a 44-year-old woman who presented with recurrent oral squamous cell carcinoma during her adulthood, without clinical haematological problem. Despite treatment with cis-retinoic acid, she developed a third squamous cell carcinoma 6 months later. In a review of the literature, only in 1 reported case was the patient treated with low-dose retinoids but he developed recurrent anal cancer after 14 months.
范科尼贫血是一种罕见的遗传性疾病，大多数患者在二三十岁时死于血液学并发症。其他患有轻度血细胞减少或无血细胞减少的患者存活时间足够长，从而发展为恶性肿瘤。本文报告了一名44岁成年女性，她在成年期出现复发性口腔鳞状细胞癌，无临床血液学问题。尽管接受了顺式维甲酸治疗，但6个月后她又患上了第三次鳞状细胞癌。在文献综述中，仅1例报告患者接受了低剂量维甲酸治疗，但14个月后他患上了复发性肛管癌。
