Slanina P, Stålhandske T
Arch Int Pharmacodyn Ther. 1977 Apr;226(2):258-62.
14-C-nicotine was incubated with 10000 X g supernatant fraction of liver homogenate from female mice (C3H/TIF/BOM) 2, 12 and 18 months old. The rate of metabolism was measured by the determination of the oxidative nicotine metabolite continine and by determining the disappearance of nicotine. No significant changes between different ages were found either in the continine formation or the rate of disappearance of nicotine.
将14-C-尼古丁与2个月、12个月和18个月大的雌性小鼠（C3H/TIF/BOM）肝脏匀浆的10000×g上清液部分一起孵育。通过测定氧化型尼古丁代谢物可替宁以及尼古丁的消失情况来测量代谢率。在可替宁的形成或尼古丁的消失率方面，未发现不同年龄之间有显著变化。
