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1
Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate-stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes.1-氨基环丙烷羧酸对大鼠海马突触体中N-甲基-D-天冬氨酸刺激的[3H]-去甲肾上腺素释放的影响。
Br J Pharmacol. 1996 Jun;118(4):901-4. doi: 10.1111/j.1476-5381.1996.tb15484.x.
2
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.GV 150526A、7-氯犬尿氨酸和HA 966可拮抗甘氨酸对N-甲基-D-天冬氨酸诱导的[3H]去甲肾上腺素和[3H]多巴胺释放的增强作用。
Eur J Pharmacol. 1997 Oct 8;336(2-3):275-81. doi: 10.1016/s0014-2999(97)01260-0.
3
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.介导海马去甲肾上腺素和纹状体多巴胺释放的N-甲基-D-天冬氨酸受体对喹啉酸、HIV-1包膜蛋白gp120、细胞外pH值及蛋白激酶C抑制表现出不同的敏感性。
J Neurochem. 2001 Jan;76(1):139-48. doi: 10.1046/j.1471-4159.2001.00057.x.
4
HIV-1 envelope protein gp120 potentiates NMDA-evoked noradrenaline release by a direct action at rat hippocampal and cortical noradrenergic nerve endings.HIV-1包膜蛋白gp120通过直接作用于大鼠海马和皮质去甲肾上腺素能神经末梢，增强NMDA诱发的去甲肾上腺素释放。
Eur J Neurosci. 1994 Nov 1;6(11):1743-9. doi: 10.1111/j.1460-9568.1994.tb00566.x.
5
Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices.茴拉西坦、1-丁基环磷腺苷和环噻嗪对大鼠海马切片中介导去甲肾上腺素释放增强的N-甲基-D-天冬氨酸（NMDA）和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体功能有不同调节作用。
Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):272-9. doi: 10.1007/pl00005352.
6
Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.调节去甲肾上腺素释放的人脑海马N-甲基-D-天冬氨酸受体受到HIV-1外壳蛋白gp120的正向调节。
AIDS. 1996 May;10(5):463-8. doi: 10.1097/00002030-199605000-00003.
7
Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells.甘氨酸位点拮抗剂和部分激动剂可抑制小脑颗粒细胞中N-甲基-D-天冬氨酸受体介导的[3H]花生四烯酸释放。
J Pharmacol Exp Ther. 1998 May;285(2):527-32.
8
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.由N-甲基-D-天冬氨酸（NMDA）和非NMDA受体介导的人大脑皮层中去甲肾上腺素释放的刺激作用。
Br J Pharmacol. 1992 May;106(1):67-72. doi: 10.1111/j.1476-5381.1992.tb14294.x.
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Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.牛磺酸增强海马体谢弗侧支轴突中的突触前N-甲基-D-天冬氨酸受体。
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Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine.大鼠海马中N-甲基-D-天冬氨酸受体介导的去甲肾上腺素释放随年龄增长而减少及D-环丝氨酸的部分恢复作用
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The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.前药4-氯犬尿氨酸通过抑制NMDA/甘氨酸B位点产生类似氯胺酮的抗抑郁作用，但无副作用。
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2
Behavioural and molecular endophenotypes in psychotic disorders reveal heritable abnormalities in glutamatergic neurotransmission.精神障碍中的行为和分子内表型揭示了谷氨酸能神经传递中的遗传异常。
Transl Psychiatry. 2015 Mar 31;5(3):e540. doi: 10.1038/tp.2015.26.

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The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.从大脑中分离神经末梢：对通过匀浆和离心获得的细胞碎片进行的电子显微镜研究。
J Anat. 1962 Jan;96(Pt 1):79-88.
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N-methyl-D-aspartic acid receptor structure and function.N-甲基-D-天冬氨酸受体的结构与功能
Physiol Rev. 1994 Jul;74(3):723-60. doi: 10.1152/physrev.1994.74.3.723.
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Kinetic study of the interactions between the glutamate and glycine recognition sites on the N-methyl-D-aspartic acid receptor complex.N-甲基-D-天冬氨酸受体复合物上谷氨酸和甘氨酸识别位点之间相互作用的动力学研究
Mol Pharmacol. 1994 Dec;46(6):1191-6.
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Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition.重组 N-甲基-D-天冬氨酸受体上的配体亲和力取决于亚基组成。
Eur J Pharmacol. 1994 Aug 16;268(3):335-45. doi: 10.1016/0922-4106(94)90058-2.
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A simple apparatus for studying the release of neurotransmitters from synaptosomes.一种用于研究神经递质从突触体释放的简易装置。
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Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes.非洲爪蟾卵母细胞中表达的N-甲基-D-天冬氨酸受体激活对甘氨酸的需求。
Science. 1988 Aug 12;241(4867):835-7. doi: 10.1126/science.2841759.
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Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates.1-氨基环丙烷羧酸盐对N-甲基-D-天冬氨酸诱导惊厥的阻断作用。
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Anxiolytic properties of 1-aminocyclopropanecarboxylic acid, a ligand at strychnine-insensitive glycine receptors.1-氨基环丙烷羧酸的抗焦虑特性，一种士的宁不敏感甘氨酸受体的配体。
Pharmacol Biochem Behav. 1989 Oct;34(2):313-6. doi: 10.1016/0091-3057(89)90317-1.
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Structural requirements for activation of the glycine coagonist site of N-methyl-D-aspartate receptors expressed in Xenopus oocytes.非洲爪蟾卵母细胞中表达的N-甲基-D-天冬氨酸受体甘氨酸共激动剂位点激活的结构要求。
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10
Indole-2-carboxylic acid: a competitive antagonist of potentiation by glycine at the NMDA receptor.吲哚 -2- 羧酸：甘氨酸在 N-甲基-D-天冬氨酸受体处发挥增强作用的竞争性拮抗剂。
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1-氨基环丙烷羧酸对大鼠海马突触体中N-甲基-D-天冬氨酸刺激的[3H]-去甲肾上腺素释放的影响。

Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate-stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes.

作者信息

Clos M V, Garcia Sanz A, Trullas R, Badia A

机构信息

Department de Farmacologia i Psiquiatria, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.

出版信息

Br J Pharmacol. 1996 Jun;118(4):901-4. doi: 10.1111/j.1476-5381.1996.tb15484.x.

DOI:10.1111/j.1476-5381.1996.tb15484.x
PMID:8799560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1909537/
Abstract
  1. The effect of 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex that exhibits neuroprotective, anxiolytic and antidepressant-like actions, was investigated in a functional assay for presynaptic NMDA receptors. 2. NMDA (100 microM) produced a 36% increase of tritium efflux above basal efflux in rat hippocampal synaptosomes preincubated with [3H]-noradrenaline ([3H]-NA), reflecting a release of tritiated noradrenaline. This effect was prevented by 10 microM 7-chlorokynurenic acid, an antagonist of the glycine site of the NMDA receptor. 3. Glycine enhanced the effect of NMDA with Emax and EC50 values of 84 +/- 11% and 1.82 +/- 0.04 microM, respectively. ACPC potentiated the effect of NMDA on tritium overflow with a lower EC50 (43 +/- 6 nM) and a lower maximal effect (Emax = 40 +/- 9%) than glycine. Furthermore, ACPC (0.1 microM) shifted the EC50 of glycine from 1.82 microM to > or = 3 mM. 4. These results show that ACPC can reduce the potentiation by glycine of NMDA-evoked [3H]-NA release and hence, may act as an antagonist at the glycine site of presynaptic hippocampal NMDA receptors when the concentration of glycine is high.
摘要
  1. 1-氨基环丙烷羧酸（ACPC）是N-甲基-D-天冬氨酸（NMDA）受体复合物甘氨酸位点的部分激动剂，具有神经保护、抗焦虑和抗抑郁样作用。本研究在突触前NMDA受体的功能测定中对其作用进行了研究。2. NMDA（100微摩尔）使预先用[3H]-去甲肾上腺素（[3H]-NA）预孵育的大鼠海马突触体中的氚流出量比基础流出量增加36%，这反映了氚化去甲肾上腺素的释放。NMDA受体甘氨酸位点的拮抗剂10微摩尔7-氯犬尿氨酸可阻止这种作用。3. 甘氨酸增强了NMDA的作用，其最大效应（Emax）和半数有效浓度（EC₅₀）分别为84±11%和1.82±0.04微摩尔。与甘氨酸相比，ACPC增强NMDA对氚溢出的作用时，其EC₅₀较低（43±6纳摩尔），最大效应也较低（Emax = 40±9%）。此外，ACPC（0.1微摩尔）将甘氨酸的EC₅₀从1.82微摩尔转变为≥3毫摩尔。4. 这些结果表明，当甘氨酸浓度较高时，ACPC可降低甘氨酸对NMDA诱发的[3H]-NA释放的增强作用，并因此可能作为突触前海马NMDA受体甘氨酸位点的拮抗剂发挥作用。