Harati Y
Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
Endocrinol Metab Clin North Am. 1996 Jun;25(2):325-59. doi: 10.1016/s0889-8529(05)70327-3.
Hyperglycemia and its vascular complications affect the entire nervous system, contributing to increased morbidity and mortality. Chronic hyperglycemia is not only a known and major risk factor for cerebral vascular diseases but also the presence of hyperglycemia at the time of a cerebrovascular event may adversely influence the outcome. It also affects the treatment of some neurodegenerative disorders, and there are suggestions that diabetes may in fact suffer from a "chronic diabetic encephalopathy." Its varied effects on the peripheral nervous system result in several forms of diabetic neuropathies, the exact pathogenesis of which is still obscure. There is, however, some new information that may link metabolic and vascular hypotheses.
高血糖及其血管并发症会影响整个神经系统，导致发病率和死亡率上升。慢性高血糖不仅是已知的脑血管疾病主要危险因素，而且脑血管事件发生时高血糖的存在可能会对预后产生不利影响。它还会影响一些神经退行性疾病的治疗，并且有观点认为糖尿病实际上可能患有“慢性糖尿病性脑病”。其对外周神经系统的多种影响导致了几种形式的糖尿病神经病变，其确切发病机制仍不清楚。然而，有一些新信息可能将代谢假说和血管假说联系起来。
