Rosenthal K L, Peterson M E
Department of Medicine, Animal Medical Center, New York, NY 10021, USA.
J Am Vet Med Assoc. 1996 Sep 15;209(6):1097-102.
To determine plasma concentrations of steroid hormones in ferrets with hyperadrenocorticism associated with adrenocortical neoplasia or nodular hyperplasia of the adrenal gland, the effect of surgical removal of the affected adrenal gland on concentrations of these hormones, and whether any hormone concentrations could be used as a marker for the disease.
Prospective case series.
32 ferrets with hyperadrenocorticism associated with adrenocortical neoplasia or nodular hyperplasia of the adrenal gland.
A blood sample was obtained from each ferret before adrenalectomy. In 26 of the 32 ferrets, a second blood sample was collected 24 to 48 hours after adrenalectomy. Plasma concentrations of 7 hormones were measured (cortisol, estradiol, testosterone, progesterone, 17-hydroxyprogesterone, androstenedione, and dehydroepiandrosterone sulfate).
Median plasma concentrations of 17-hydroxyprogesterone, androstenedione, and dehydroepiandrosterone sulfate were significantly higher in ferrets with adrenal gland disease, compared with concentrations in clinically normal ferrets. After adrenalectomy, median concentrations of estradiol, 17-hydroxyprogesterone, and androstenedione decreased significantly. Of 23 ferrets in which concentrations of estradiol, 17-hydroxyprogesterone, and androstenedione all were measured, 22 (96%) had high concentrations of at least 1 of these 3 hormones, but only 5 (22%) ferrets had high concentrations of all 3 hormones.
The condition that develops in ferrets with adrenal gland disease apparently is caused by excessive secretion of 1 or more steroids other than cortisol. Because concentration of a particular hormone was not high in all ferrets, we recommend determining plasma concentrations of several sex steroids, including androstenedione, 17-hydroxyprogesterone, and estradiol.
测定患有与肾上腺皮质肿瘤或肾上腺结节性增生相关的肾上腺皮质功能亢进的雪貂体内类固醇激素的血浆浓度，切除患病肾上腺对这些激素浓度的影响，以及是否有任何激素浓度可作为该疾病的标志物。
前瞻性病例系列研究。
32只患有与肾上腺皮质肿瘤或肾上腺结节性增生相关的肾上腺皮质功能亢进的雪貂。
在肾上腺切除术之前，从每只雪貂采集一份血样。在32只雪貂中的26只中，在肾上腺切除术后24至48小时采集第二份血样。测定7种激素的血浆浓度（皮质醇、雌二醇、睾酮、孕酮、17-羟孕酮、雄烯二酮和硫酸脱氢表雄酮）。
与临床正常雪貂的浓度相比，患有肾上腺疾病的雪貂体内17-羟孕酮、雄烯二酮和硫酸脱氢表雄酮的血浆中位数浓度显著更高。肾上腺切除术后，雌二醇、17-羟孕酮和雄烯二酮的中位数浓度显著下降。在23只同时测定了雌二醇、17-羟孕酮和雄烯二酮浓度的雪貂中，22只（96%）至少有一种这三种激素的浓度较高，但只有5只（22%）雪貂三种激素的浓度都高。
雪貂患肾上腺疾病时出现的状况显然是由皮质醇以外的一种或多种类固醇过度分泌引起的。由于并非所有雪貂中特定激素的浓度都高，我们建议测定几种性类固醇的血浆浓度，包括雄烯二酮（androstenedione）、17-羟孕酮和雌二醇。
