降钙素基因相关肽可拮抗肾上腺髓质素对组胺诱导的支气管收缩的保护作用。

Calcitonin gene-related peptide antagonizes the protective effect of adrenomedullin on histamine-induced bronchoconstriction.

Kanazawa H, Kawaguchi T, Kamoi H, Fujii T, Kudoh S, Hirata K, Kurihara N, Yoshikawa J

First Department of Internal Medicine, Osaka City University Medical School, Japan.

Clin Exp Pharmacol Physiol. 1996 Jun-Jul;23(6-7):472-5. doi: 10.1111/j.1440-1681.1996.tb02763.x.

Abstract

In the present study the possible relationship between adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) in the regulation of airway functions in anaesthetized guinea-pigs was examined in vivo. 2. We found that AM significantly inhibited histamine-induced bronchoconstriction in a dose-dependent manner. CGRP or the CGRP receptor antagonist (CGRP [8-37]) alone did not affect pulmonary resistance and pretreatment with CGRP or CGRP [8-37] did not significantly affect histamine-induced bronchoconstriction. However, AM-induced bronchoprotection was significantly inhibited by pretreatment with CGRP or CGRP [8-37] in a dose-dependent manner. 3. It is therefore possible that CGRP may be competitive, at least in part, with binding sites of AM in the guinea-pig airway. Exogenous AM may be useful for the management of bronchial asthma, not only as a potent bronchodilator, but also as a functional antagonist of CGRP.

摘要

在本研究中，我们在体内研究了麻醉豚鼠气道功能调节中肾上腺髓质素（AM）与降钙素基因相关肽（CGRP）之间可能的关系。2. 我们发现，AM以剂量依赖性方式显著抑制组胺诱导的支气管收缩。单独使用CGRP或CGRP受体拮抗剂（CGRP [8-37]）不影响肺阻力，用CGRP或CGRP [8-37]预处理也不会显著影响组胺诱导的支气管收缩。然而，用CGRP或CGRP [8-37]预处理以剂量依赖性方式显著抑制了AM诱导的支气管保护作用。3. 因此，CGRP可能至少部分地与豚鼠气道中AM的结合位点竞争。外源性AM不仅作为一种有效的支气管扩张剂，而且作为CGRP的功能拮抗剂，可能对支气管哮喘的治疗有用。