在健康的年轻和中年男性中，血清胰岛素样生长因子I和胰岛素样生长因子结合蛋白1水平与血清游离睾酮及性激素结合球蛋白水平相关。

Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men.

作者信息

Erfurth E M, Hagmar L E, Sääf M, Hall K

机构信息

Department of Internal Medicine, University of Lund, Sweden.

出版信息

Clin Endocrinol (Oxf). 1996 Jun;44(6):659-64. doi: 10.1046/j.1365-2265.1996.731552.x.

DOI:10.1046/j.1365-2265.1996.731552.x

PMID:8801037

Abstract

OBJECTIVE

Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.

DESIGN AND PATIENTS

The associations between the serum levels of IGF-I and IGFBP-1 on one hand, and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle-aged men.

RESULTS

Serum levels of IGF-I decreased both with increasing age (r = -0.66, P < 0.001) and increasing SHBG levels (r = -0.46, P = 0.002), but increased with increasing free testosterone (f-testosterone) (r = 0.42, P = 0.005). These associations remained after mutual simultaneous adjustments in a multiple regression analysis. IGFBP-1 did not display any significant univariate correlation with age (r = -0.25, P = 0.06) or SHBG (r = 0.18, P = 0.14), but showed a significant positive correlation with both f-testosterone (r = 0.42, P = 0.004), and total testosterone (t-testosterone) (r = 0.39, P = 0.008). In a multiple regression analysis IGFBP-1 was positively correlated with both SHBG and f-testosterone, but not with t-testosterone.

CONCLUSION

The present study suggests that among healthy young and middle-aged men, there is an association between serum levels of free-testosterone and SHBG on the one hand, and serum IGF-I and IGFBP-1 on the other.

摘要

目的

据报道，对于患有单纯性低促性腺激素性性腺功能减退的男性，给予睾酮可提高血清胰岛素样生长因子-I（IGF-I）水平。在生长激素缺乏的儿童中，血清IGF-I与性激素结合球蛋白（SHBG）呈负相关。IGF-I的生物学作用被认为受结合蛋白的影响，其中之一是胰岛素样生长因子结合蛋白-1（IGFBP-1），它不仅是一种载体蛋白，还能积极调节IGF-I的细胞作用。这些观察结果提示血清中IGF-I、IGFBP-1、睾酮和SHBG之间存在关联。本研究的目的是在正常健康男性中调查这些关联。

设计与患者

在38名正常健康的中青年男性中，研究了一方面血清IGF-I和IGFBP-1水平，与另一方面睾酮和SHBG水平之间的关联。

结果

血清IGF-I水平随年龄增长（r = -0.66，P < 0.001）和SHBG水平升高（r = -0.46，P = 0.002）而降低，但随游离睾酮（f-睾酮）升高而升高（r = 0.42，P = 0.005）。在多元回归分析中进行相互同时调整后，这些关联仍然存在。IGFBP-1与年龄（r = -0.25，P = 0.06）或SHBG（r = 0.18，P = 0.14）未显示任何显著的单变量相关性，但与f-睾酮（r = 0.42，P = 0.004）和总睾酮（t-睾酮）（r = 0.39，P = 0.008）均显示显著正相关。在多元回归分析中，IGFBP-1与SHBG和f-睾酮均呈正相关，但与t-睾酮无关。