Erfurth E M, Hagmar L E, Sääf M, Hall K
Department of Internal Medicine, University of Lund, Sweden.
Clin Endocrinol (Oxf). 1996 Jun;44(6):659-64. doi: 10.1046/j.1365-2265.1996.731552.x.
Administration of testosterone has been reported to increase serum levels of IGF-I in men with isolated hypogonadotrophic hypogonadism. An inverse relation between serum IGF-I and sex hormone binding globulin (SHBG) is seen in GH deficient children. The biological action of IGF-I is thought to be influenced by binding proteins, one of which is insulin-like growth factor-binding protein-1 (IGFBP-1), which is not only a carrier protein but also actively regulates the cellular actions of IGF-I. These observations suggest associations between IGF-I, IGFBP-1, testosterone and SHBG in serum. The aim of the present study was to investigate these associations in normal healthy men.
The associations between the serum levels of IGF-I and IGFBP-1 on one hand, and testosterone and SHBG on the other were investigated in 38 normal healthy young and middle-aged men.
Serum levels of IGF-I decreased both with increasing age (r = -0.66, P < 0.001) and increasing SHBG levels (r = -0.46, P = 0.002), but increased with increasing free testosterone (f-testosterone) (r = 0.42, P = 0.005). These associations remained after mutual simultaneous adjustments in a multiple regression analysis. IGFBP-1 did not display any significant univariate correlation with age (r = -0.25, P = 0.06) or SHBG (r = 0.18, P = 0.14), but showed a significant positive correlation with both f-testosterone (r = 0.42, P = 0.004), and total testosterone (t-testosterone) (r = 0.39, P = 0.008). In a multiple regression analysis IGFBP-1 was positively correlated with both SHBG and f-testosterone, but not with t-testosterone.
The present study suggests that among healthy young and middle-aged men, there is an association between serum levels of free-testosterone and SHBG on the one hand, and serum IGF-I and IGFBP-1 on the other.
据报道，对于患有单纯性低促性腺激素性性腺功能减退的男性，给予睾酮可提高血清胰岛素样生长因子-I（IGF-I）水平。在生长激素缺乏的儿童中，血清IGF-I与性激素结合球蛋白（SHBG）呈负相关。IGF-I的生物学作用被认为受结合蛋白的影响，其中之一是胰岛素样生长因子结合蛋白-1（IGFBP-1），它不仅是一种载体蛋白，还能积极调节IGF-I的细胞作用。这些观察结果提示血清中IGF-I、IGFBP-1、睾酮和SHBG之间存在关联。本研究的目的是在正常健康男性中调查这些关联。
在38名正常健康的中青年男性中，研究了一方面血清IGF-I和IGFBP-1水平，与另一方面睾酮和SHBG水平之间的关联。
血清IGF-I水平随年龄增长（r = -0.66，P < 0.001）和SHBG水平升高（r = -0.46，P = 0.002）而降低，但随游离睾酮（f-睾酮）升高而升高（r = 0.42，P = 0.005）。在多元回归分析中进行相互同时调整后，这些关联仍然存在。IGFBP-1与年龄（r = -0.25，P = 0.06）或SHBG（r = 0.18，P = 0.14）未显示任何显著的单变量相关性，但与f-睾酮（r = 0.42，P = 0.004）和总睾酮（t-睾酮）（r = 0.39，P = 0.008）均显示显著正相关。在多元回归分析中，IGFBP-1与SHBG和f-睾酮均呈正相关，但与t-睾酮无关。
本研究表明，在健康的中青年男性中，一方面游离睾酮和SHBG的血清水平，与另一方面血清IGF-I和IGFBP-1之间存在关联。
