金刚烷衍生物对谷氨酸能和胆碱能离子通道的阻断作用。 - Suppr

Blockade of glutamate- and cholinergic ion channels by amantadane derivatives.

作者信息

Magazanik L G, Antonov S M, Potap'eva N N, Gmiro V E, Johnson J

机构信息

I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences:, Saint Petersburg, Russia.

出版信息

Neurosci Behav Physiol. 1996 Jan-Feb;26(1):13-22. doi: 10.1007/BF02391151.

DOI:10.1007/BF02391151

PMID:8801464

Abstract

摘要

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Blockade of glutamate- and cholinergic ion channels by amantadane derivatives.金刚烷衍生物对谷氨酸能和胆碱能离子通道的阻断作用。

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Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants.新型金刚烷衍生物可作为开放配体门控通道的阻滞剂和抗惊厥剂。

Mol Pharmacol. 1995 Mar;47(3):558-67.

[The blockade of glutaminergic and cholinergic ion channels by adamantane derivatives].

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Trapping channel block of NMDA-activated responses by amantadine and memantine.金刚烷胺和美金刚对NMDA激活反应的捕获通道阻滞作用

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The molecular basis of anticholinesterase actions on nicotinic and glutamatergic synapses.

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Effect of intracerebral administration of NMDA and AMPA on dopamine and glutamate release in the ventral pallidum and on motor behavior.脑室内注射N-甲基-D-天冬氨酸（NMDA）和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）对腹侧苍白球中多巴胺和谷氨酸释放及运动行为的影响。

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Interaction of bicyclo-octane analogs of amantadine with ionic channels of the nicotinic acetylcholine receptor and electrically excitable membrane.

J Pharmacol Exp Ther. 1984 Jan;228(1):73-9.

D1-like dopamine receptors selectively block P/Q-type calcium channels to reduce glutamate release onto cholinergic basal forebrain neurones of immature rats.D1样多巴胺受体选择性阻断P/Q型钙通道，以减少未成熟大鼠胆碱能基底前脑神经元上谷氨酸的释放。

J Physiol. 2007 Apr 1;580(Pt 1):103-17. doi: 10.1113/jphysiol.2006.125724. Epub 2007 Jan 18.

[A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats].[MK-801、美金刚、金刚烷胺、吡仑和IEM-1754对完整大鼠中枢H-胆碱能阻断和NMDA阻断作用的比较研究]

Eksp Klin Farmakol. 2000 Mar-Apr;63(2):16-20.

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Direct inhibition of the N-methyl-D-aspartate receptor channel by dopamine and (+)-SKF38393.多巴胺和(+)-SKF38393对N-甲基-D-天冬氨酸受体通道的直接抑制作用

Br J Pharmacol. 1999 Apr;126(8):1847-55. doi: 10.1038/sj.bjp.0702479.

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Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.清醒小鼠脑内注射药物所产生的药理效应。

Br J Pharmacol Chemother. 1957 Mar;12(1):12-5. doi: 10.1111/j.1476-5381.1957.tb01354.x.

Nicotinic acetylcholine receptor at 9 A resolution.分辨率为9埃的烟碱型乙酰胆碱受体。

J Mol Biol. 1993 Feb 20;229(4):1101-24. doi: 10.1006/jmbi.1993.1107.

Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.人类 N-甲基-D-天冬氨酸受体关键亚基的分子克隆与染色体定位

J Biol Chem. 1993 Feb 15;268(5):3728-33.

Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide.临床耐受性NMDA拮抗剂的前景：开放通道阻滞剂与一氧化氮的替代氧化还原状态

Trends Neurosci. 1993 Dec;16(12):527-32. doi: 10.1016/0166-2236(93)90198-u.

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines.兴奋性氨基酸拮抗剂的治疗潜力：通道阻滞剂和2,3-苯二氮䓬类药物。

Trends Pharmacol Sci. 1993 Sep;14(9):325-31. doi: 10.1016/0165-6147(93)90005-5.

Kinetic analysis of atropine-induced alterations in bullfrog ganglionic fast synaptic currents.阿托品诱导牛蛙神经节快速突触电流变化的动力学分析。

J Physiol. 1983 Apr;337:137-58. doi: 10.1113/jphysiol.1983.sp014616.

Structure-activity relationships of amantadine. I. Interaction of the N-alkyl analogues with the ionic channels of the nicotinic acetylcholine receptor and electrically excitable membrane.金刚烷胺的构效关系。I. N-烷基类似物与烟碱型乙酰胆碱受体离子通道和电可兴奋膜的相互作用。

Mol Pharmacol. 1982 Jul;22(1):82-93.

Transformations in the abdominal muscles of the blue blow-fly, Calliphora erythrocephala (Meig), during metamorphosis.红头丽蝇（Calliphora erythrocephala (Meig)）变态过程中腹部肌肉的变化。

J Embryol Exp Morphol. 1965 Aug;14(1):89-110.

Ionic blockage of sodium channels in nerve.神经中钠通道的离子阻断

J Gen Physiol. 1973 Jun;61(6):687-708. doi: 10.1085/jgp.61.6.687.

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.抗惊厥药物MK-801是一种有效的N-甲基-D-天冬氨酸拮抗剂。

Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8. doi: 10.1073/pnas.83.18.7104.

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Blockade of glutamate- and cholinergic ion channels by amantadane derivatives.

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