催产素在人胎盘中被一种酶水解，该酶与妊娠血清中的催产素酶相同。

Oxytocin is hydrolyzed by an enzyme in human placenta that is identical to the oxytocinase of pregnancy serum.

作者信息

Naruki M, Mizutani S, Goto K, Tsujimoto M, Nakazato H, Itakura A, Mizuno K, Kurauchi O, Kikkawa F, Tomoda Y

机构信息

Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.

出版信息

Peptides. 1996;17(2):257-61. doi: 10.1016/0196-9781(95)02124-8.

DOI:10.1016/0196-9781(95)02124-8

PMID:8801531

Abstract

The hydrolysis of oxytocin (OT) by human placental subcellular fractions and pregnant sera was studied in the presence of bestatin, a potent inhibitor of aminopeptidases, and the antibody against pregnant serum oxyotocinase (P-LAP)(EC 3.4 11.3) by measuring liberated amino acids by high performance liquid chromatography (HPLC). Our immunotitration study and the effect of bastatin on the oxytocin-degrading protease showed that the initiating and responsible protease in oxyotocin degradation in human placenta and pregnant serum is P-LAP.

摘要

在氨肽酶的强效抑制剂贝抑素以及抗妊娠血清催产素酶（P-LAP，EC 3.4 11.3）抗体存在的情况下，通过高效液相色谱法（HPLC）测定释放的氨基酸，研究了人胎盘亚细胞组分和妊娠血清对催产素（OT）的水解作用。我们的免疫滴定研究以及贝抑素对催产素降解蛋白酶的作用表明，人胎盘和妊娠血清中催产素降解的起始和主要蛋白酶是P-LAP。