Neville J R
Aviat Space Environ Med. 1977 May;48(5):409-12.
The potential effect of changes in the position and shape of the oxyhemoglobin dissociation curve (ODC) in modifying altitude tolerance is quantitatively analyzed and discussed. The most frequently used criteria for oxygen affinity, the position or P50 of the ODC (oxygen pressure at 50% saturation) is shown to have slight influence on tissue oxygenation in terms of arteriovenous oxygen difference under steady-state, hypoxic-hypoxia conditions. Conversely, changes in the shape of the curve, also expressed as the cooperativity or heme-heme interaction, could substantially modify oxygen transport under these conditions. Published observations are reviewed which suggest that hemoglobin cooperativity is not normally invariant.
本文对氧合血红蛋白解离曲线（ODC）的位置和形状变化在改变海拔耐受性方面的潜在影响进行了定量分析和讨论。最常用的氧亲和力标准，即ODC的位置或P50（50%饱和度时的氧分压），在稳态、低氧-低氧条件下，就动静脉氧差而言，对组织氧合的影响较小。相反，曲线形状的变化，也表现为协同性或血红素-血红素相互作用，在这些条件下可能会显著改变氧运输。本文回顾了已发表的观察结果，这些结果表明血红蛋白的协同性通常并非一成不变。
