Vasan N S, Lash J W
Biochem J. 1977 Apr 15;164(1):179-83. doi: 10.1042/bj1640179.
Proteoglycan heterogeneity was studied during the maturation of embryonic-chick limb cartilage in vivo. The results suggest that during the differentiation of limb-bud cartilage the aggregated forms of proteoglycans increase between stages 24 and 35, whereas the non-aggregated or monomeric forms decrease. Only one link protein is found in stage-24 limb buds, whereas two are present at stage 35. Evidence suggests that the synthesis of link proteins may be a regulatory factor in limb chondrogenesis.
在体内对鸡胚肢体软骨成熟过程中的蛋白聚糖异质性进行了研究。结果表明，在肢体芽软骨分化过程中，蛋白聚糖的聚集形式在第24至35阶段之间增加，而非聚集或单体形式减少。在第24阶段的肢体芽中仅发现一种连接蛋白，而在第35阶段存在两种。有证据表明连接蛋白的合成可能是肢体软骨形成中的一个调节因子。
