Okoyama S, Nakayama K, Kudo M
Department of Anatomy, School of Medicine, Kanazawa University, Japan.
Neuroreport. 1996 Apr 10;7(5):1067-71. doi: 10.1097/00001756-199604100-00023.
Acetylcholinesterase (AChE) and calbindin D-28K (CaBP) are transiently expressed in the rat auditory nuclei during the early postnatal period. In the ventral division of the medial geniculate body (MGV), the transient AChE expression in the neuropil is replaced by CaBP expression in the neurones. The time correlation between the up- and down-regulations in these neuro-chemicals suggests some switching over mechanism. A lesion of the inferior colliculus (IC) decreases the AChE reactivity in terminal field of the IC-MGV projections. We here demonstrate that the IC lesion results in CaBP expressions in neurones of the MGV before its normal onset. It is thus possible that the transiently expressed AChE plays an important role in the intercellular signal transduction for neurochemical phenotype expressions.
乙酰胆碱酯酶（AChE）和钙结合蛋白D - 28K（CaBP）在出生后早期的大鼠听觉核中短暂表达。在内侧膝状体腹侧部（MGV），神经毡中短暂的AChE表达被神经元中的CaBP表达所取代。这些神经化学物质上调和下调之间的时间相关性提示了某种转换机制。下丘（IC）损伤会降低IC - MGV投射终末场中的AChE反应性。我们在此证明，IC损伤导致MGV神经元在其正常开始表达CaBP之前就出现CaBP表达。因此，短暂表达的AChE可能在神经化学表型表达的细胞间信号转导中起重要作用。
