Broccardo M, Improta G, Brandoni A, Tabacco A
Institute of Pharmacology, University La Sapienza, Rome, Italy.
Peptides. 1996;17(4):729-31. doi: 10.1016/0196-9781(96)00052-6.
In an in vivo study of salivation in rats, the scialogogic effects of two natural and amphibian tachykinins, PG-SPI and PG-KII, which activate distinct tachykinin receptors, were compared with those of the tachykinins substance P, neurokinin A and B, and kassinin. The rank order of potencies of these peptides injected intravenously on salivation was: PG-SPI = SP > or = PG-KII = KASS > NKA > > NKB. Atropine (1 mg/kg. i.v.) had no effect on PG-SPI-, SP-, and NKA-induced salivation, but reduced that stimulated by PG-KII and KASS. We conclude that PG-SPI and PG-KII increase salivary secretion through different mechanisms and that rat salivary glands contain PG-SPI-and PG-KII-sensitive receptors.
在一项关于大鼠唾液分泌的体内研究中，将两种激活不同速激肽受体的天然两栖类速激肽PG - SPI和PG - KII的催涎作用，与速激肽P物质、神经激肽A和B以及肛褶蛙肽的催涎作用进行了比较。静脉注射这些肽对唾液分泌的效价排序为：PG - SPI = P物质≥PG - KII = 肛褶蛙肽＞神经激肽A＞＞神经激肽B。阿托品（1毫克/千克，静脉注射）对PG - SPI、P物质和神经激肽A诱导的唾液分泌没有影响，但减少了PG - KII和肛褶蛙肽刺激引起的唾液分泌。我们得出结论，PG - SPI和PG - KII通过不同机制增加唾液分泌，并且大鼠唾液腺含有对PG - SPI和PG - KII敏感的受体。
