肾上腺皮质腺瘤所致原发性醛固酮增多症患者的肾脏病理改变

Renal pathology in patients with primary hyperaldosteronism secondary to an adrenal cortical adenoma.

作者信息

Grady R W, Kaylor W M, Lee J C, Bravo E L, Gephardt G N, Novick A C

机构信息

Department of Urology, Cleveland Clinic Foundation, OH 44195, USA.

出版信息

Urology. 1996 Sep;48(3):369-72. doi: 10.1016/S0090-4295(96)00166-5.

DOI:10.1016/S0090-4295(96)00166-5

PMID:8804487

Abstract

OBJECTIVES

The cause of persistent hypertension following the removal of an aldosterone-producing adrenal adenoma is unknown. The purpose of this study was to determine whether this occurrence is due to existing renal histopathologic damage.

METHODS

Thirty-two patients with primary hyperaldosteronism due to an aldosterone-secreting adrenal cortical adenoma underwent open renal biopsy at the time of unilateral adrenalectomy. Biopsy results were correlated with the duration and severity of hypertension before and after surgery.

RESULTS

Nineteen patients were cured of their hypertension postoperatively, whereas 13 patients had persistent diastolic hypertension. Statistical analysis of these two groups revealed no difference when renal histopathologic variables, preoperative severity of hypertension, or preoperative duration of hypertension were compared.

CONCLUSIONS

Persistent hypertension in these patients does not appear to be due to renal histopathologic changes; coexisting essential hypertension is a more likely cause.

摘要