两性霉素B脂质复合物治疗一名患有播散性茄病镰刀菌感染的白血病儿童。

Amphotericin B lipid complex treatment of a leukemic child with disseminated Fusarium solani infection.

作者信息

Patterson T S, Barton L L, Shehab Z M, Hutter J J

机构信息

Department of Pediatrics, University of Arizona, Tucson 85724, USA.

出版信息

Clin Pediatr (Phila). 1996 May;35(5):257-60. doi: 10.1177/000992289603500505.

DOI:10.1177/000992289603500505

PMID:8804544

Abstract

We report a case of Fusarium solani infection in a 2 1/2-year-old girl with acute lymphoblastic leukemia and severe neutropenia. The infection, initially limited to her sinuses, became disseminated, as evidenced by the development of a characteristic cutaneous lesion on her left leg after a cumulative dose of amphotericin B of 18.3 mg/kg. Amphotericin B lipid complex (ABLC), 5 mg/kg/day, in conjunction with repeated surgical debridement of the sinuses and correction of neutropenia with granulocyte colony stimulating factor (GCSF), led to clinical and mycologic cure.

摘要

我们报告了一例2岁半患急性淋巴细胞白血病并伴有严重中性粒细胞减少症的女童感染茄病镰刀菌的病例。感染最初局限于鼻窦，后来扩散，在两性霉素B累积剂量达到18.3mg/kg后，她左腿出现典型皮肤损伤就是证据。每天5mg/kg的两性霉素B脂质复合体（ABLC），联合对鼻窦反复进行外科清创术以及用粒细胞集落刺激因子（GCSF）纠正中性粒细胞减少症，最终实现了临床和真菌学治愈。