Stern J M
Department of Psychology, Rutgers University, New Brunswick, NJ 08903, USA.
Physiol Behav. 1996 Jul;60(1):187-90. doi: 10.1016/0031-9384(96)00016-9.
Profound deficits in maternal behavior occur following postpartum bilateral infraorbital denervation (IO-X), with substantial recovery 12-24 h later. In the present experiment, primiparous rats were subjected to IO-X or sham surgery on gestation day 22. Whereas parturition behavior was normal in controls, it was severely disrupted in all IO-X dams. Impairments included absent, abbreviated, or delayed perioral behaviors-nest building, participation in delivery, placentophagia, licking and retrieval of pups-accompanied by increased general activity and delayed onset of nursing. There was increased mortality in the litters of IO-X dams at birth and by postpartum day (PD) 3, and impaired retrieval by IO-X dams on PD1-3. A surgery-birth interval of < 7 h vs. > or = 22 h was associated only with poor litter growth. Thus, prepartum IO-X disrupts onset of maternal behavior during parturition, with long-term consequences for offspring well-being.
产后双侧眶下神经去支配（IO-X）后会出现严重的母性行为缺陷，但在12 - 24小时后会有显著恢复。在本实验中，初产大鼠在妊娠第22天接受IO-X手术或假手术。对照组的分娩行为正常，而所有接受IO-X手术的母鼠的分娩行为均受到严重干扰。行为障碍包括口周行为缺失、缩短或延迟——筑巢、参与分娩、食胎盘、舔舐和找回幼崽——同时伴有总体活动增加和哺乳开始延迟。IO-X母鼠的幼崽在出生时和产后第3天的死亡率增加，且IO-X母鼠在产后第1 - 3天找回幼崽的能力受损。手术至出生间隔< 7小时与≥22小时相比，仅与幼崽生长不良有关。因此，产前IO-X会干扰分娩期间母性行为的开始，并对后代的健康产生长期影响。
