全反式维甲酸影响发育中的神经管中孤儿受体COUP-TF I和COUP-TF II的表达。

All-trans retinoic acid affects the expression of orphan receptors COUP-TF I and COUP-TF II in the developing neural tube.

作者信息

Brubaker K, McMillan M, Neuman T, Nornes H O

机构信息

Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA.

出版信息

Brain Res Dev Brain Res. 1996 May 31;93(1-2):198-202. doi: 10.1016/0165-3806(96)00007-7.

DOI:10.1016/0165-3806(96)00007-7

PMID:8804707

Abstract

The effect of all-trans retinoic acid (RA) on chicken ovalbumin upstream promoter-transcription factor (COUP-TF) I and COUP-TF II expression in the developing cervical spinal cord and telencephalon was examined using embryonic day 11 and 13 mice. All-trans RA treatment results in changes in expression of COUP-TF I and COUP-TF II genes in the spinal cord and telencephalon. COUP-TF I mRNA levels were reduced in the spinal cord ventricular zone (VZ) after treatment, whereas in the telencephalon, mRNA levels were unaffected in the VZ and increased in the intermediate zone (IZ). COUP-TF II mRNA levels were increased in the spinal cord VZ after treatment, while in the telencephalon, IZ mRNA levels were decreased in the E11 embryos and increased in E13 embryos.

摘要

利用胚胎第11天和13天的小鼠，研究了全反式维甲酸（RA）对发育中的颈脊髓和端脑中鸡卵清蛋白上游启动子转录因子（COUP-TF）I和COUP-TF II表达的影响。全反式RA处理导致脊髓和端脑中COUP-TF I和COUP-TF II基因表达发生变化。处理后，脊髓室管膜区（VZ）中COUP-TF I mRNA水平降低，而在端脑中，VZ中的mRNA水平未受影响，中间区（IZ）中的mRNA水平升高。处理后，脊髓VZ中COUP-TF II mRNA水平升高，而在端脑中，E11胚胎的IZ mRNA水平降低，E13胚胎的IZ mRNA水平升高。