幽门螺杆菌传播：与甲型肝炎病毒比较的证据。

Helicobacter pylori transmission: evidence from a comparison with hepatitis A virus.

作者信息

Webb P M, Knight T, Newell D G, Elder J B, Forman D

机构信息

Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, UK.

出版信息

Eur J Gastroenterol Hepatol. 1996 May;8(5):439-41.

PMID:8804871

Abstract

OBJECTIVE

To assess the possibility that faecal-oral contact might play a role in the transmission of Helicobacter pylori.

DESIGN

A cross-sectional comparison of the patterns of hepatitis A and H. pylori seropositivity.

METHODS

At interview, blood samples and questionnaire data were collected from a group of 467 male volunteers, aged 18-65, from Stoke-on-Trent, UK. Serum samples from each subject were then analysed for anti-H. pylori and anti-hepatitis A antibodies.

RESULTS

Overall, 100 of 175 H. pylori seropositive subjects (57.1%) and 113 of 292 H. pylori seronegative subjects (38.7%) were hepatitis A seropositive (chi 2 = 15.0, P < 0.001). This difference was not statistically significant after adjustment for age group and father's occupation, as a surrogate for socioeconomic status in childhood (P = 0.15). The seroprevalence of hepatitis A increased with age at a rate of 2.3% per year, compared to only 1.0% per year for H. pylori (P = 0.015).

CONCLUSION

These data suggest that the case for faecal-oral transmission of H. pylori, in a manner similar to the spread of hepatitis A, is not proven and that other modes of transmission, for instance through oral-oral contact, should also be considered.

摘要

目的

评估粪口接触在幽门螺杆菌传播中可能发挥作用的可能性。

设计

甲型肝炎和幽门螺杆菌血清阳性模式的横断面比较。

方法

在访谈中，从英国特伦特河畔斯托克的一组467名年龄在18至65岁之间的男性志愿者中收集血液样本和问卷数据。然后对每个受试者的血清样本进行抗幽门螺杆菌和抗甲型肝炎抗体分析。

结果

总体而言，175名幽门螺杆菌血清阳性受试者中有100名（57.1%），292名幽门螺杆菌血清阴性受试者中有113名（38.7%）甲型肝炎血清阳性（χ² = 15.0，P < 0.001）。在按年龄组和父亲职业进行调整后，这种差异无统计学意义，父亲职业作为童年社会经济地位的替代指标（P = 0.15）。甲型肝炎的血清流行率随年龄增长，每年上升2.3%，而幽门螺杆菌仅为每年1.0%（P = 0.015）。