Turkel S B, Overturf G D
Cancer. 1977 Jul;40(1):226-33. doi: 10.1002/1097-0142(197707)40:1<226::aid-cncr2820400135>3.0.co;2-1.
A 59-year-old man is presented who had immunoblastic lymphadenopathy which evolved over a three-year period into immunoblastic sarcoma. His course was complicated by vaccinia necrosum, which necessitated prolonged therapy with Marboran and vaccinia-immune globulin. The persistence of virus was documented at autopsy by positive viral culture and ultra-structural examination. This case illustrates the potential hazards of administration of live viral vaccines to an immune compromised host presumed to be in remission and suggests that the continued activity of viral infection may signal the unsuspected persistence of underlying disease.
一名59岁男性患者，患有免疫母细胞性淋巴结病，病程长达三年，之后演变成免疫母细胞肉瘤。其病情因牛痘坏死而复杂化，需要长期使用马尔波罗（异环磷酰胺）和牛痘免疫球蛋白进行治疗。尸检时通过病毒培养阳性和超微结构检查证实病毒持续存在。该病例说明了对假定处于缓解期的免疫功能低下宿主接种活病毒疫苗的潜在危害，并表明病毒感染的持续活动可能预示着潜在疾病的未被怀疑的持续存在。
