源自1型人类免疫缺陷病毒包膜的裂解序列或跨膜结构域（gp41）的多分支肽构建体的抗HIV活性。
Anti-HIV activity of multibranched peptide constructs derived either from the cleavage sequence or from the transmembrane domain (gp41) of the human immunodeficiency virus type 1 envelope.
作者信息
Sabatier J M, Mabrouk K, Moulard M, Rochat H, Van Rietschoten J, Fenouillet E
机构信息
CNRS URA 1455, Institut Fédératif de Recherche Jean Roche, Faculté de Médecine Nord, Marseille, France.
出版信息
Virology. 1996 Sep 15;223(2):406-8. doi: 10.1006/viro.1996.0496.
Multibranched peptides (SPCs) derived either from the fusion protein (gp41) sequence or from the cleavage sequence of the human immunodeficiency virus type 1 envelope were chemically synthesized and tested for their ability to inhibit both syncytium formation and HIV production in CD4+ cells. The gp41-derived SPCs had no effect. In contrast, an SPC encompassing the envelope cleavage sites strongly inhibited both HIV Env-induced syncytium formation and viral production.
化学合成了源自融合蛋白（gp41）序列或1型人类免疫缺陷病毒包膜裂解序列的多分支肽（SPC），并测试了它们抑制CD4+细胞中合胞体形成和HIV产生的能力。源自gp41的SPC没有效果。相反，一个包含包膜裂解位点的SPC强烈抑制了HIV Env诱导的合胞体形成和病毒产生。
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