Kunes J, Kohoutová M, Zicha J
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Am J Hypertens. 1996 Jul;9(7):675-80. doi: 10.1016/0895-7061(96)00023-4.
The objective of this study was to evaluate whether the major histocompatibility complex of the rat can be related to blood pressure (BP) level and BP response to stress. Blood pressure was determined under light ether anesthesia or during moderate restraint stress in normotensive Lewis rats, in rat strains congenic with respect to their RT1 haplotype [LEW.1A (RT1a) and LEW.1W (RT1u)], and in their recombinant lines LEW.1AR1 (RT1ar1), LEW.1AR2 (RT1ar2), LEW.1WR1 (RT1wr1), and LEW.1WR2 (RT1wr2). Under light ether anesthesia, systolic blood pressure was similar in Lewis, LEW.1A, and LEW.1W rats. There were also no significant differences in blood pressure in LEW.1AR1 and LEW.1AR2 animals when compared with Lewis or LEW.1A rats. In contrast, BP was significantly increased in LEW.1WR2 rats. On the other hand, moderate restraint stress induced a BP increase in animals of all recombinant lines compared to the respective congenic strains. These results confirmed our previous finding in recombinant inbred strains about the significant role of RT1 complex in BP regulation. Moreover, our data indicated that BP can be influenced by interaction of individual regions of the RT1 complex on the genetic background of Lewis strain.
本研究的目的是评估大鼠的主要组织相容性复合体是否与血压水平及血压对应激的反应有关。在轻度乙醚麻醉下或在中度束缚应激期间，测定正常血压的Lewis大鼠、在RT1单倍型[LEW.1A (RT1a)和LEW.1W (RT1u)]方面同基因的大鼠品系及其重组系LEW.1AR1 (RT1ar1)、LEW.1AR2 (RT1ar2)、LEW.1WR1 (RT1wr1)和LEW.1WR2 (RT1wr2)的血压。在轻度乙醚麻醉下，Lewis大鼠、LEW.1A大鼠和LEW.1W大鼠的收缩压相似。与Lewis大鼠或LEW.1A大鼠相比，LEW.1AR1和LEW.1AR2动物的血压也无显著差异。相比之下，LEW.1WR2大鼠的血压显著升高。另一方面，与各自的同基因品系相比，中度束缚应激在所有重组系动物中均诱导血压升高。这些结果证实了我们先前在重组近交系中关于RT1复合体在血压调节中的重要作用的发现。此外，我们的数据表明，在Lewis品系的遗传背景下，RT1复合体各个区域的相互作用可影响血压。
