全身给药的氨苄西林、苄青霉素和氟氯西林在糖尿病大鼠和正常大鼠切除伤口中的分布以及局部外用血管扩张剂治疗的效果
Distribution of systemically administered ampicillin, benzylpenicillin, and flucloxacillin in excisional wounds in diabetic and normal rats and effects of local topical vasodilator treatment.
作者信息
Cross S E, Thompson M J, Roberts M S
机构信息
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
出版信息
Antimicrob Agents Chemother. 1996 Jul;40(7):1703-10. doi: 10.1128/AAC.40.7.1703.
The present study assessed the suitability of the streptozotocin-treated diabetic rat as a model for the study of diabetes-impaired wound healing. The distribution of three antibiotics, ampicillin, benzylpenicillin, and flucloxacillin, in wound and adjacent tissue sites on the abdomens and legs of normal and diabetic rats was determined 30 min after intravenous administration of a single bolus containing 50 mg of all three antibiotics per kg of body weight. Tissue/plasma ratios showed that antibiotic tissue penetration appeared to be related to protein binding. The treatment of wound sites with vasodilators (1% solution) to increase local blood flow and antibiotic delivery to the site was then determined and appeared to be more effective with endothelium-independent sodium nitroprusside than with endothelium-dependent acetylcholine in diabetic rats. These results suggest that coadministration of topical vasodilators to wound sites in neuropathic diabetic patients undergoing antibiotic therapy for infected ulcers could increase antibiotic delivery to wound tissue sites.
本研究评估了链脲佐菌素诱导的糖尿病大鼠作为糖尿病伤口愈合受损研究模型的适用性。在静脉注射每千克体重含50毫克这三种抗生素的单次推注后30分钟，测定了正常大鼠和糖尿病大鼠腹部和腿部伤口及相邻组织部位三种抗生素（氨苄西林、苄青霉素和氟氯西林）的分布。组织/血浆比率表明，抗生素的组织渗透似乎与蛋白结合有关。随后测定了用血管扩张剂（1%溶液）处理伤口部位以增加局部血流和抗生素向该部位递送的情况，在糖尿病大鼠中，与内皮依赖性乙酰胆碱相比，内皮非依赖性硝普钠似乎更有效。这些结果表明，在接受感染性溃疡抗生素治疗的神经性糖尿病患者的伤口部位联合应用局部血管扩张剂可增加抗生素向伤口组织部位的递送。
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