对“背甲”基因的遗传分析，“背甲”基因是果蝇中背侧组织存活和刚毛定位所必需的基因。
A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila.
作者信息
Heitzler P, Haenlin M, Ramain P, Calleja M, Simpson P
机构信息
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France.
出版信息
Genetics. 1996 Jul;143(3):1271-86. doi: 10.1093/genetics/143.3.1271.
Abstract
A genetic and phenotypic analysis of the gene pannier is described. Animals mutant for strong alleles die as embryos in which the cells of the amnioserosa are prematurely lost. This leads to a dorsal cuticular hole. The dorsal-most cells of the imagos are also affected: viable mutants exhibit a cleft along the dorsal midline. pannier mRNA accumulates specifically in the dorsal-most regions of the embryo and the imaginal discs. Viable mutants and mutant combinations also affect the thoracic and head bristle patterns in a complex fashion. Only those bristles within the area of expression of pannier are affected. A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles.
摘要
本文描述了对基因“背兜”的遗传和表型分析。强等位基因突变的动物在胚胎期死亡，此时羊膜浆膜的细胞过早丢失，导致背部表皮出现孔洞。成虫最背部的细胞也受到影响：存活的突变体在背中线处出现裂缝。“背兜”mRNA特异性地在胚胎和成虫盘的最背部区域积累。存活的突变体和突变体组合也以复杂的方式影响胸部和头部刚毛的模式，只有在“背兜”表达区域内的刚毛受到影响。已经研究了大量的等位基因，结果表明“背兜”可能对“无刚毛”和“具刚毛”基因的表达有相反的影响，导致刚毛的丢失或增加。
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A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila.对“背甲”基因的遗传分析，“背甲”基因是果蝇中背侧组织存活和刚毛定位所必需的基因。
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本文引用的文献
1
Genetic Analysis of the Achaete-Scute System of DROSOPHILA MELANOGASTER.黑腹果蝇 Achaete-Scute 系统的遗传分析。
Genetics. 1979 Mar;91(3):491-520. doi: 10.1093/genetics/91.3.491.
2
Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.人类骨形态发生蛋白序列可在果蝇胚胎中赋予正常的背腹模式。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2905-9. doi: 10.1073/pnas.90.7.2905.
3
Programmed cell death during Drosophila embryogenesis.果蝇胚胎发育过程中的程序性细胞死亡。
Development. 1993 Jan;117(1):29-43. doi: 10.1242/dev.117.1.29.
4
A reconsideration of the mechanism of position effect.位置效应机制的再探讨。
Genetics. 1994 Sep;138(1):1-5. doi: 10.1093/genetics/138.1.1.
5
Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation.Hairy作为果蝇感觉器官形成的一种DNA结合螺旋-环-螺旋阻遏物发挥作用。
Genes Dev. 1994 Nov 15;8(22):2743-55. doi: 10.1101/gad.8.22.2743.
6
The helix-loop-helix extramacrochaetae protein is required for proper specification of many cell types in the Drosophila embryo.螺旋-环-螺旋超大刚毛蛋白是果蝇胚胎中许多细胞类型正确特化所必需的。
Development. 1994 Sep;120(9):2555-66. doi: 10.1242/dev.120.9.2555.
7
Embryonic expression and function of the Drosophila helix-loop-helix gene, extramacrochaetae.果蝇螺旋-环-螺旋基因extra macrochaetae的胚胎表达与功能
Mech Dev. 1994 Jul;47(1):65-72. doi: 10.1016/0925-4773(94)90096-5.
8
pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1.腹袋蛋白是果蝇中achaete和scute的负调控因子，编码一种与脊椎动物转录因子GATA-1具有同源性的锌指蛋白。
Development. 1993 Dec;119(4):1277-91. doi: 10.1242/dev.119.4.1277.
9
A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster.一种GATA家族转录因子在黑腹果蝇胚胎的背腹轴上表达。
Development. 1993 Dec;119(4):1055-65. doi: 10.1242/dev.119.4.1055.
10
Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster.与黑腹果蝇触角足基因复合体相关的突变体胚胎发育缺陷。
Dev Biol. 1984 Mar;102(1):147-72. doi: 10.1016/0012-1606(84)90182-9.
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