van der Heijden M H, Helders G M, Booms G H, Huisman E A, Rombout J H, Boon J H
Department of Fish Culture and Fisheries, Wageningen Agricultural University, The Netherlands.
Vet Immunol Immunopathol. 1996 Jun 15;52(1-2):127-34. doi: 10.1016/0165-2427(95)05532-0.
The effect of the antibacterial drugs flumequine (FQ) and oxytetracycline (OTC) on the defence system of the European eel (Anguilla anguilla L., 1758) was investigated using an experimentally induced infection with the parasitic swimbladder nematode Anguillicola crassus. Eight weeks after oral administration of infective larvae, the mean recovery of the parasites in FQ-treated eels was lower than in non-medicated control animals, and significantly lower than in OTC-treated eels. Mean numbers of peripheral blood granulocytes and B-lymphocytes, as well as the total number of circulating lymphoid cells, showed a significant increase as a result of the infection, while drug treatment merely affected the quantity of the lymphoid cells. The difference in protection against the parasite after FQ or OTC administration points to a modulation of the fish resistance as a result of the drug treatment. The results favour a modulation of the cellular rather than the humoral response, as no specific antibodies were found.
利用寄生性鳔线虫粗厚鳗鲡线虫进行实验性感染，研究了抗菌药物氟甲喹（FQ）和土霉素（OTC）对欧洲鳗鲡（Anguilla anguilla L.，1758）防御系统的影响。口服感染性幼虫8周后，FQ处理的鳗鱼体内寄生虫的平均回收率低于未用药的对照动物，且显著低于OTC处理的鳗鱼。外周血粒细胞和B淋巴细胞的平均数，以及循环淋巴细胞的总数，因感染而显著增加，而药物处理仅影响淋巴细胞的数量。FQ或OTC给药后对寄生虫的保护差异表明，药物处理导致鱼类抵抗力发生了调节。由于未发现特异性抗体，结果支持细胞反应而非体液反应的调节。
