5-羟色胺1b受体在大鼠压力诱导的行为和神经化学紊乱中的作用。

Role of 5-HT1b receptor in the pressure-induced behavioral and neurochemical disorders in rats.

作者信息

Kriem B, Abraini J H, Rostain J C

机构信息

Laboratoire de Physiopathologie Respiratoire Intégrée et Cellulaire, Equipe de Neurobiologie en Conditions Extrêmes, CNRS-URA, Marseille, France.

出版信息

Pharmacol Biochem Behav. 1996 Feb;53(2):257-64. doi: 10.1016/0091-3057(95)00209-x.

DOI:10.1016/0091-3057(95)00209-x

PMID:8808129

Abstract

When human divers and experimental animals are exposed to increasing environmental pressure, they develop the high-pressure neurologic syndrome (HPNS) that has been recently demonstrated to include an increase in striatal dopamine (DA) release. This increase has been correlated with enhanced locomotor and motor activity (LMA). In the present study, we investigated the effect of the 5-HT1b receptor antagonist (+/-)cyanopindolol, which has been shown to block at normal pressure the increase in striatal DA release induced by the administration of the 5-HT1b receptor agonist CGS 12066B. Our data clearly showed that the administration of (+/-)cyanopindolol partially blocked both the pressure-induced increase in striatal DA release and the development of LMA. These results suggest the contribution of the 5-HT neurotransmission in the DA-related neurochemical and behavioral disorders that occur in rats exposed to high pressure.

摘要

当人类潜水员和实验动物暴露于不断增加的环境压力时，他们会出现高压神经综合征（HPNS），最近已证明该综合征包括纹状体多巴胺（DA）释放增加。这种增加与运动和肌肉活动（LMA）增强相关。在本研究中，我们研究了5-HT1b受体拮抗剂（±）氰吲哚洛尔的作用，已证明该拮抗剂在常压下可阻断5-HT1b受体激动剂CGS 12066B给药诱导的纹状体DA释放增加。我们的数据清楚地表明，（±）氰吲哚洛尔的给药部分阻断了压力诱导的纹状体DA释放增加和LMA的发展。这些结果表明5-羟色胺神经传递在暴露于高压的大鼠中发生的与多巴胺相关的神经化学和行为障碍中起作用。