纳曲吲哚，一种δ阿片受体拮抗剂，可阻断摇头丸增强对奖励性脑刺激按压的能力。

Naltrindole, a delta-opioid antagonist, blocks MDMA's ability to enhance pressing for rewarding brain stimulation.

作者信息

Reid L D, Hubbell C L, Tsai J, Fishkin M D, Amendola C A

机构信息

Laboratory for Psychopharmacology, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA.

出版信息

Pharmacol Biochem Behav. 1996 Feb;53(2):477-80. doi: 10.1016/0091-3057(95)02020-9.

DOI:10.1016/0091-3057(95)02020-9

PMID:8808161

Abstract

Twelve rats were each fixed with a chronically indwelling bipolar electrode for stimulation of the medial forebrain bundle as it courses through the hypothalamus. These rats were trained to press a bar for intracranial stimulation of 0.3-s trains of 60 Hz sine waves for 10 min daily at three intensities. One intensity was just above threshold for maintaining pressing, one intensity was a high intensity that sustained considerable pressing, but not maximum pressing, and the other was intermediate to the others. After stable rates of pressing were obtained, rats received MDMA daily. MDMA significantly increased rates of pressing. Prior to a day when rats received MDMA, they also received an injection of naltrindole, a selective delta-opioid receptor antagonist. Naltrindole blocked MDMA's enhancement of pressing for reinforcing brain stimulation.

摘要

十二只大鼠每只都被长期植入一个双极电极，用于刺激穿过下丘脑的内侧前脑束。这些大鼠经过训练，每天以三种强度按压杠杆，以接受持续0.3秒、频率为60赫兹的正弦波颅内刺激，每次刺激持续10分钟。一种强度刚好高于维持按压的阈值，一种强度较高，能维持相当程度的按压，但不是最大按压，另一种强度介于两者之间。在获得稳定的按压速率后，大鼠每天接受摇头丸。摇头丸显著提高了按压速率。在大鼠接受摇头丸的前一天，它们还接受了一次纳曲吲哚注射，纳曲吲哚是一种选择性δ-阿片受体拮抗剂。纳曲吲哚阻断了摇头丸对强化脑刺激的按压增强作用。