用于卡马西平控释的醋酸丁酸纤维素微粒

Cellulose acetate butyrate microparticles for controlled release of carbamazepine.

作者信息

Arnaud P, Boué C, Chaumeil J C

机构信息

Faculté de Pharmacie de Paris, Laboratoire de Pharmacie Galénique, France.

出版信息

J Microencapsul. 1996 Jul-Aug;13(4):407-17. doi: 10.3109/02652049609026027.

DOI:10.3109/02652049609026027

PMID:8808778

Abstract

Cellulose acetate butyrate microparticles loaded in carbamazepine were prepared by a solvent evaporation technique. A decrease of the amount of organic solvent (from 80 to 40 ml of methylene chloride) increased the microparticle average diameter (73-111 and 207 microns) and decreased the carbamazepine release rate (T50% increased from 3.3 to 16.8 and 166.4 min). The microparticle area under the curve at 120 min was similar to that obtained with Tegretol LP 200 tablets.

摘要

采用溶剂蒸发技术制备了负载卡马西平的醋酸丁酸纤维素微粒。有机溶剂用量的减少（从80毫升二氯甲烷降至40毫升）使微粒平均直径增大（从73微米增至111微米和207微米），并降低了卡马西平的释放速率（T50%从3.3分钟增至16.8分钟和166.4分钟）。120分钟时微粒的曲线下面积与得理多LP 200片相似。