Maa Y F, Hsu C
Department of Pharmaceutical Research and Development, Genentech, Inc., South San Francisco, CA 94080, USA.
J Microencapsul. 1996 Jul-Aug;13(4):419-33. doi: 10.3109/02652049609026028.
4e report a feasibility study on liquid-liquid emulsification by static mixers for use in microencapsulation. This study was concerned with developing a quantitative correlation between the size of the microspheres and process parameters. The process parameters considered included operational variables and physical properties associated with both the dispersion and dispersed phases. The effect of mixing element design on mixing efficiency and particle-size distribution was evaluated using three different static mixers. The performance of static mixers and conventional continuously stirred-tank reactors was assessed in several different aspects. Dimensional analysis was used to establish a correlation based on protein-free poly(lactic acid-co-glycolid acid) and poly(methyl methacrylate) microspheres in an oil-in-water emulsion using 1/4", 1/2" and 1" static mixers. This correlation accurately described the preparation of protein-loaded microspheres and provided large-scale microsphere production with a empirical basis.
4e报道了一项关于用于微囊化的静态混合器进行液-液乳化的可行性研究。该研究关注于建立微球尺寸与工艺参数之间的定量关联。所考虑的工艺参数包括操作变量以及与分散相和连续相相关的物理性质。使用三种不同的静态混合器评估了混合元件设计对混合效率和粒径分布的影响。从几个不同方面评估了静态混合器和传统连续搅拌釜式反应器的性能。利用量纲分析，在水包油乳液中，基于无蛋白的聚（乳酸-共-乙醇酸）和聚（甲基丙烯酸甲酯）微球，使用1/4英寸、1/2英寸和1英寸的静态混合器建立了一种关联。这种关联准确地描述了载蛋白微球的制备，并为大规模微球生产提供了经验基础。
