连接肽（1-18）和组胺对体外培养的人肾上腺皮质细胞脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）生成的影响。

Effects of joining peptide (1-18) and histamine on dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) production of human adrenocortical cells in vitro.

作者信息

Orsó E, Szalay K S, Szabó D, Stark E, Fehér T, Perner F, Hidvégi M

机构信息

Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.

出版信息

J Steroid Biochem Mol Biol. 1996 May;58(2):207-10. doi: 10.1016/0960-0760(96)00027-1.

DOI:10.1016/0960-0760(96)00027-1

PMID:8809202

Abstract

Joining peptide 1-18 (JP 1-18), added alone in concentrations of 10(-13)-10(-7) M to collagenase-dispersed human adrenocortical cells, did not affect the basal production of corticosterone, cortisol, aldosterone, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS). JP 1-18 potentiated the ACTH-stimulated production of steroids. When administered in combination with histamine (10(-8)-10(-3) M), JP 1-18 (10(-8) or 10(-10) M), enhanced the synthesis of DHEA and DHEAS. JP 1-18, together with histamine, may play a role in the regulation of DHEA and DHEAS production.

摘要

单独添加浓度为10⁻¹³ - 10⁻⁷ M的连接肽1 - 18（JP 1 - 18）至胶原酶分散的人肾上腺皮质细胞，对皮质酮、皮质醇、醛固酮、脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）的基础分泌没有影响。JP 1 - 18增强了促肾上腺皮质激素（ACTH）刺激的类固醇分泌。当与组胺（10⁻⁸ - 10⁻³ M）联合使用时，JP 1 - 18（10⁻⁸或10⁻¹⁰ M）可增强DHEA和DHEAS的合成。JP 1 - 18与组胺一起，可能在DHEA和DHEAS分泌的调节中发挥作用。