Matsumura R, Kagami M, Tomioka H, Tanabe E, Sugiyama T, Sueishi M, Nakajima A, Azuma M, Okumura K
Department of Internal Medicine, Toho University School of Medicine, Sakura Hospital, Japan.
Clin Exp Rheumatol. 1996 May-Jun;14(3):309-11.
The expression of Fas antigen on ductal epithelial cells of sialoadenitis was examined in patients with Sjögren's syndrome (SS) and in normal subjects.
Minor salivary glands from the SS patients were examined by an immunohistochemical method using a new monoclonal antibody to the Fas antigen.
In two patients with severe sialoadenitis, Fas was strongly expressed on the ductal epithelial cells. By contrast, the Fas antigen was not seen in the minor salivary glands of normal subjects nor in those with mild sialoadenitis.
This finding suggests that the Fas antigen may play a role in the pathogenesis of sialoadenitis in SS by providing a specific target for cytotoxic T cells expressing the Fas ligand.
检测干燥综合征（SS）患者及正常受试者涎腺炎导管上皮细胞上Fas抗原的表达情况。
采用一种针对Fas抗原的新型单克隆抗体，通过免疫组织化学方法检测SS患者的小涎腺。
在两名重度涎腺炎患者中，导管上皮细胞上Fas呈强表达。相比之下，正常受试者及轻度涎腺炎患者的小涎腺中未见Fas抗原。
这一发现表明，Fas抗原可能通过为表达Fas配体的细胞毒性T细胞提供特异性靶点，在SS涎腺炎的发病机制中发挥作用。
